| Name | PK1 |
|---|---|
| Synonyms | Black mamba toxin related protein; PRK 1; PRK1; EG VEGF; EGVEGF; Endocrine gland derived vascular endothelial growth factor; Mambakine; PK1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1282722 | Mohrmann M, Pauli A, Ritzer M, Schonfeld B, Seifert B, Brandis M: Inhibition of -dependent transport systems in LLC-PK1 cells by metabolites of ifosfamide. Ren Physiol Biochem. 1992 Nov-Dec;15(6):289-301. We used the permanent renal epithelial cell line LLC-PK1 in order to investigate whether major metabolites of IF (i.e. 4-OH-IF, acrolein and chloracetyldehyde) induced the transport defects most frequently detected after IF therapy in vivo. |
84(1,1,1,4) | Details |
| 7506438 | Mohrmann M, Pauli A, Walkenhorst H, Schonfeld B, Brandis M: Effect of ifosfamide metabolites on -dependent transport in a model of proximal tubular cells (LLC-PK1) in culture. Ren Physiol Biochem. 1993 Nov-Dec;16(6):285-98. We used a permanent renal epithelial cell line with proximal tubular characteristics (LLC-PK1) in order to investigate the effects of IF and some of its major metabolites (4-OH-IF, chloracetaldehyde, and acrolein). |
33(0,1,1,3) | Details |
| 7517170 | Mohrmann M, Ansorge S, Schmich U, Schonfeld B, Brandis M: Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture. Pediatr Nephrol. 1994 Apr;8(2):157-63. We used the renal epithelial cell line LLC-PK1, which has many properties of the proximal tubule, in order to investigate the toxicity of IF and CP and of their reactive metabolites 4--IF (4-OH-IF), 4--CP (4-OH-CP), acrolein and chloroacetaldehyde (CAA). |
31(0,1,1,1) | Details |
| 1504259 | Hashmi M, Vamvakas S, Anders MW: Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl- the of acrolein. Chem Res Toxicol. 1992 May-Jun;5(3):360-5. Hence the release of acrolein from 1 and 2 was studied in chemical systems, and their cytotoxicity was investigated in cultured LLC-PK1 cells and in isolated rat renal proximal tubular cells. |
6(0,0,1,1) | Details |
| 7542792 | Mohrmann M, Kupper N, Schonfield B, Brandis M: Ifosfamide and mesna: effects on the Na/H exchanger activity in renal epithelial cells in culture (LLC-PK1). Ren Physiol Biochem. 1995 May-Jun;18(3):118-27. We tested the major IF metabolites 4-hydroperoxy-IF (4-OOH-IF), chloroacetaldehyde (CAA), and acrolein. |
3(0,0,0,3) | Details |
| 7524598 | Mohrmann M, Ansorge S, Schonfeld B, Brandis M: Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells. Pediatr Nephrol. 1994 Aug;8(4):458-65. MESNA completely prevented the toxic effects of acrolein and of 4-OOH-CP. Using the renal tubular cell line LLC-PK1, we investigated whether there is a protective effect of either MESNA or of its major metabolite DIMESNA, in combination with metabolites of IF or CP, on incorporation, incorporation or total protein. |
1(0,0,0,1) | Details |