| Name | SOD2 |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17197552 | Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J: Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)- Invest Ophthalmol Vis Sci. 2007 Jan;48(1):339-48. RESULTS: Acute acrolein exposure exceeding 50 microM (24 hours) in ARPR19 cells caused toxicity, including decreases in cell viability, mitochondrial potential, GSH, antioxidant capacity, Nrf2 expression, enzyme activity (mitochondrial complexes I, II, III; superoxide dismutase; and peroxidase). |
81(1,1,1,1) | Details |
| 3603576 | Patel JM: Stimulation of cyclophosphamide-induced pulmonary microsomal lipid peroxidation by Toxicology. 1987 Jul;45(1):79-91. To test this, rat lung microsomes were treated in vitro with CP or acrolein in the presence of and 0-100% O2 with and without superoxide dismutase (SOD), (GSH), (DTT), and EDTA (agents which scavenge reactive O2 species and/or detoxify reactive metabolites). |
31(0,1,1,1) | Details |
| 17069868 | Awe SO, Adeagbo AS, D'Souza SE, Bhatnagar A, Conklin DJ: Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism. Toxicol Appl Pharmacol. 2006 Dec 15;217(3):266-76. Epub 2006 Aug 26. Pretreatment with 6-(2-propargyloxyphenyl) hexanoic acid (PPOH 50 microM), an epoxygenase inhibitor, or the superoxide dismutase mimetic Tempol (100 microM) significantly attenuated acrolein-induced vasodilatation. |
31(0,1,1,1) | Details |
| 16403964 | Bilinski T, Kwolek M, Sas E, Krynicka M, Koziol S, Owsiak-Teleon A, Krzepilko A, Bartosz G: A novel test for identifying genes involved in detoxification in the yeast. Biofactors. 2005;24(1-4):59-65. This attitude enabled to an unexpected detection increased sensitivity of mutants devoid of CuZn-superoxide dismutase (CuZnSOD) to allyl (precursor of acrolein) and nonenol. |
6(0,0,1,1) | Details |
| 9567773 | Arumugam N, Sivakumar V, Thanislass J, Devaraj H: Effects of acrolein on rat liver antioxidant defense system. Indian J Exp Biol. 1997 Dec;35(12):1373-4. Following 45 days of acrolein exposure, the levels of and the activity of catalase were decreased whereas the activities of superoxide dismutase and peroxidase were increased. |
6(0,0,1,1) | Details |
| 18501200 | Ansari MA, Roberts KN, Scheff SW: Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med. 2008 Aug 15;45(4):443-52. Epub 2008 May 3. At various times post-TBI, animals were killed and the hippocampus was analyzed for antioxidants (GSH, peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, superoxide dismutase, and catalase) and oxidants (acrolein, protein carbonyl, and |
6(0,0,1,1) | Details |
| 8149893 | Kanekal S, Kehrer JP: Metabolism of cyclophosphamide by lipoxygenases. . Drug Metab Dispos. 1994 Jan-Feb;22(1):74-8. (0.1 mM), superoxide dismutase (10 units), and nordihydroguaiaretic acid (0.1 mM) significantly decreased acrolein generation by 74, 76, and 77%, respectively. |
6(0,0,1,1) | Details |
| 12921788 | Al-Maghrebi MA, Al-Mulla F, Benov LT: induces apoptosis in a human breast cancer cell line. Arch Biochem Biophys. 2003 Sep 1;417(1):123-7. Activated phagocytes employ myeloperoxidase to generate and acrolein. Using breast cancer cells, we demonstrate that inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. |
1(0,0,0,1) | Details |
| 18258206 | Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, Shen W, Packer L, Cotman CW, Liu J: protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2008 Apr 1;44(7):1465-74. Epub 2008 Jan 18. Acrolein, a major component of cigarette smoke and a product of lipid peroxidation, was used to induce oxidative mitochondrial damage in RPE cells. And, total antioxidant capacity, content, glutathione S-transferase, and superoxide dismutase activities and expression of nuclear factor-E2-related factor 2 were increased by LM relative to LA. |
1(0,0,0,1) | Details |
| 17076691 | Gowder SJ, Devaraj H: Effect of the food flavour on the antioxidant status of rat kidney. Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):379-82. The non-enzymatic antioxidants and were decreased while the antioxidant enzymes, superoxide dismutase, peroxidase and glutathione-s-transferase were increased. |
1(0,0,0,1) | Details |
| 16781455 | Shao C, Roberts KN, Markesbery WR, Scheff SW, Lovell MA: Oxidative stress in head trauma in aging. Free Radic Biol Med. 2006 Jul 1;41(1):77-85. Epub 2006 Apr 3. Analysis of (4-HNE) and acrolein, by-products of lipid peroxidation, shows significant (P < 0.05) age-dependent increases in ipsilateral (IP) hippocampus 1 and 7 days post injury. Comparison of antioxidant enzyme activities shows significant (P < 0.05) age-dependent decreases of manganese superoxide dismutase in IP hippocampus and cortex 1 and 7 days post injury. |
1(0,0,0,1) | Details |
| 19515016 | Iuchi Y, Okada F, Takamiya R, Kibe N, Tsunoda S, Nakajima O, Toyoda K, Nagae R, Suematsu M, Soga T, Uchida K, Fujii J: Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes. Biochem J. 2009 Aug 13;422(2):313-20. We found that the SOD1 [Cu,Zn-SOD (superoxide dismutase)] gene deficiency causes anaemia, the production of autoantibodies against RBCs (red blood cells) and renal damage. The production of antibodies against lipid peroxidation products, and acrolein, as well as autoantibodies against RBCs and carbonic anhydrase II were elevated in the SOD1 (-/-) mice, but were suppressed in the SOD1 (-/-);hSOD1 (tg/+) mice. |
1(0,0,0,1) | Details |
| 17401128 | Liu-Snyder P, Logan MP, Shi R, Smith DT, Borgens RB: Neuroprotection from secondary injury by polyethylene glycol requires its internalization. J Exp Biol. 2007 Apr;210(Pt 8):1455-62. Addition of potent free radical scavengers such as or superoxide dismutase (SOD) is able to interfere with this process, but PEG is not. Acrolein can pass through cell membranes with ease, inducing progressive LPO in ;bystander' cells, and the production of even more acrolein by inducing its own production. |
1(0,0,0,1) | Details |
| 20153624 | Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Feb 12. Consequently, the expression and/or activity of the following Phase II enzymes increased: glutamate cysteine ligase, NAD (P) H:quinone oxidoreductase 1, heme-oxygenase 1, glutathione S-transferase and superoxide dismutase; total antioxidant capacity and also increased. |
1(0,0,0,1) | Details |
| 18607771 | Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, Li Y: Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol. 2008 Fall;8(3):115-25. Epub 2008 Jul 8. Here we report that incubation of rat aortic smooth muscle A10 cells with (0.25-5 microM) resulted in concentration-dependent induction of a spectrum of important cellular antioxidants and phase 2 enzymes, including superoxide dismutase (SOD), catalase, the reduced form of (GSH), peroxidase, glutathione reductase (GR), glutathione S-transferase (GST), and NAD (P) H:quinone oxidoreductase 1 (NQO1). Pretreatment with (0.5, 1, and 5 microM) protected aortic smooth muscle cells from oxidative and electrophilic cytotoxicity induced by xanthine oxidase (XO)/ H2O2, SIN-1-derived and acrolein. |
1(0,0,0,1) | Details |
| 16362626 | Shamoto-Nagai M, Maruyama W, Yi H, Akao Y, Tribl F, Gerlach M, Osawa T, Riederer P, Naoi M: Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome. J Neural Transm. 2006 May;113(5):633-44. Epub 2005 Dec 16. Superoxide dismutase and deferoxamine completely suppressed the increase, indicating that produced by an iron-mediated reaction plays a central role. |
1(0,0,0,1) | Details |
| 12466639 | Grdina DJ, Murley JS, Kataoka Y: Radioprotectants: current status and new directions. Oncology. 2002;63 Suppl 2:2-10. Among other novel approaches to radioprotection being explored are methods to increase levels of the antioxidant mitochondrial enzyme manganese superoxide dismutase (MnSOD). |
1(0,0,0,1) | Details |
| 20149621 | Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J: protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J Nutr Biochem. 2010 Feb 9. Studies in this laboratory have previously shown that the major antioxidant polyphenol in olives, protects ARPE-19 human retinal pigment epithelial cells from oxidative damage induced by acrolein, an environmental toxin and endogenous end product of lipid oxidation, that occurs at increased levels in age-related macular degeneration lesions. The activation of Nrf2 led to activation of phase II detoxifying enzymes, including gamma-glutamyl-cysteinyl-ligase, -quinone-oxidoreductase 1, heme-oxygenase-1, superoxide dismutase, peroxiredoxin and thioredoxin as well as other antioxidant enzymes, while the activation of PPARGC1alpha led to increased protein expression of mitochondrial transcription factor A, uncoupling protein 2 and mitochondrial complexes. |
1(0,0,0,1) | Details |
| 4029094 | Patel JM, Block ER: Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung. Exp Lung Res. 1985;8(2-3):153-65. We hypothesized that cyclophosphamide or one of its toxic metabolites, acrolein, may potentiate O2 toxicity by depressing lung antioxidant defense mechanisms. Excised lungs were analyzed for (GSH) content, glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GSH-R), peroxidase (GSH-P), and superoxide dismutase (SOD) activities. |
1(0,0,0,1) | Details |
| 19749434 | Cimini A, Moreno S, D'Amelio M, Cristiano L, D'Angelo B, Falone S, Benedetti E, Carrara P, Fanelli F, Cecconi F, Amicarelli F, Ceru MP: Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer's disease: a role for peroxisomes. J Alzheimers Dis. 2009 Jan 1;18(4):935-52. The expression and localization of peroxisomal (PMP70, CAT, AOX, and THL) and peroxisome-related proteins (PEX5p, GPX1, SOD1, and SOD2) were studied in the neocortex and hippocampus of transgenic and wild-type animals. Oxidative stress markers (TBARS, acrolein, and 8-OHG) were also evaluated. |
1(0,0,0,1) | Details |
| 10079053 | Arumugam N, Sivakumar V, Thanislass J, Pillai KS, Devaraj SN, Devaraj H: Acute pulmonary toxicity of acrolein in rats--underlying mechanism. . Toxicol Lett. 1999 Feb 22;104(3):189-94. The activities of catalase and peroxidase were reduced whereas an increase in the activities of superoxide dismutase was observed. |
1(0,0,0,1) | Details |
| 16275026 | Misonou Y, Asahi M, Yokoe S, Miyoshi E, Taniguchi N: Acrolein produces through the elevation of intracellular levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy. Nitric Oxide. 2006 Mar;14(2):180-7. Epub 2005 Nov 7. |
0(0,0,0,0) | Details |
| 13678534 | Schaefer S, Kajimura M, Tsuyama S, Uchida K, Sato E, Inoue M, Suematsu M, Watanabe K: Aberrant utilization of and regulation of soluble guanylate cyclase in rat diabetic retinopathy. Antioxid Redox Signal. 2003 Aug;5(4):457-65. Regional lipid peroxidation was also examined by an anti-acrolein MoAb. |
0(0,0,0,0) | Details |