| Name | CASP9 |
|---|---|
| Synonyms | APAF 3; APAF3; Apoptotic protease MCH6; Apoptotic protease Mch 6; Apoptotic protease activating factor 3; CASP 9; CASP9; CASPASE 9c… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17320762 | Tanel A, Averill-Bates DA: Activation of the death receptor pathway of apoptosis by the acrolein. Free Radic Biol Med. 2007 Mar 15;42(6):798-810. Epub 2006 Dec 14. Activation of the mitochondrial pathway by acrolein was confirmed by caspase-9 activation. |
93(0,3,3,3) | Details |
| 17204747 | Tanel A, Averill-Bates DA: Inhibition of acrolein-induced apoptosis by the antioxidant J Pharmacol Exp Ther. 2007 Apr;321(1):73-83. Epub 2007 Jan 4. NAC also inhibited procaspase-9 processing, activation of enzymatic activity of caspase-9, -7, and -8, and poly (ADP- polymerase cleavage induced by acrolein. |
81(1,1,1,1) | Details |
| 19041681 | Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel R: Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-) sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicology. 2009 Jan 31;255(3):151-9. Epub 2008 Nov 6. BEAS-2B cells were exposed during 6, 10, and 24h to the respiratory sensitizers ammonium hexachloroplatinate IV, hexamethylene diisocyanate, and trimellitic anhydride, the irritants acrolein and methyl and the skin sensitizer 1-chloro-2,4-dinitrobenzene. The 10 most discriminative genes were BC042064, A_24_P229834, DOCK11, THC2544911, DLGAP4, NINJ1, PFKM, FLJ10986, IL28RA, and CASP9. |
1(0,0,0,1) | Details |
| 15843039 | Tanel A, Averill-Bates DA: The acrolein induces apoptosis via activation of the mitochondrial pathway. Biochim Biophys Acta. 2005 Apr 15;1743(3):255-67. Epub 2005 Jan 5. Acrolein induced apoptosis through a decrease in mitochondrial membrane potential, the liberation of cytochrome c, the activation of initiator caspase-9, and the activation of the effector caspase-7. |
81(1,1,1,1) | Details |
| 19596284 | Roy J, Pallepati P, Bettaieb A, Tanel A, Averill-Bates DA: Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chem Biol Interact. 2009 Oct 7;181(2):154-67. Epub 2009 Jul 9. Acrolein (3-27microM, 30-60min) activated early stage processes in the mitochondrial pathway of apoptosis, such as Bax translocation to mitochondria, cytochrome c release, caspase-9 activation, and translocation of apoptosis-inducing factor to the nucleus. |
31(0,1,1,1) | Details |
| 11723234 | Schwartz PS, Waxman DJ: Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. . Mol Pharmacol. 2001 Dec;60(6):1268-79. Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. |
4(0,0,0,4) | Details |