| Name | TRPV1 |
|---|---|
| Synonyms | Capsaicin receptor; OTRPC 1; Osm 9 like TRP channel 1; TRP vanilloid 1; TRPV 1; TRPV1; Transient receptor potential cation channel subfamily V member 1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18031925 | Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Hogestatt ED, Zygmunt PM: Distribution and function of the -sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol. 2008 Feb;53(2):391-9. Epub 2007 Oct 22. All TRPA1 immunoreactive nerves fibres also expressed TRPV1 immunoreactivity and vice versa. |
1(0,0,0,1) | Details |
| 17728277 | Albin KC, Carstens MI, Carstens E: Modulation of oral heat and cold pain by irritant chemicals. Chem Senses. 2008 Jan;33(1):3-15. Epub 2007 Aug 29. mustard oil, and may induce heat hyperalgesia via enhanced thermal gating of TRPV1 that is coexpressed with TRPA1 in peripheral nociceptors. |
1(0,0,0,1) | Details |
| 17314320 | Niforatos W, Zhang XF, Lake MR, Walter KA, Neelands T, Holzman TF, Scott VE, Faltynek CR, Moreland RB, Chen J: Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597). Mol Pharmacol. 2007 May;71(5):1209-16. Epub 2007 Feb 21. However, various agonists have been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent natural products [e.g., (ITC), allicin, and |
0(0,0,0,0) | Details |
| 17950047 | Hazari MS, Rowan WH, Winsett DW, Ledbetter AD, Haykal-Coates N, Watkinson WP, Costa DL: Potentiation of pulmonary reflex response to 24h following whole-body acrolein exposure is mediated by TRPV1. Respir Physiol Neurobiol. 2008 Feb 1;160(2):160-71. Epub 2007 Sep 15. |
164(2,2,2,4) | Details |
| 18445509 | Wang ZY, Wang P, Merriam FV, Bjorling DE: Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain. 2008 Sep 30;139(1):158-67. Epub 2008 Apr 28. We investigated participation of TRPV1 in visceral pain associated with bladder inflammation induced in mice by systemic treatment with cyclophosphamide or intravesical instillation of acrolein. |
11(0,0,1,6) | Details |
| 19220220 | Alenmyr L, Hogestatt ED, Zygmunt PM, Greiff L: TRPV1-mediated itch in seasonal allergic rhinitis. . Allergy. 2009 May;64(5):807-10. Epub 2009 Feb 13. |
7(0,0,0,7) | Details |
| 18568077 | Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R: Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008 Jul;118(7):2574-82. We hypothesized that 2 alpha,beta-unsaturated aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ion channel coexpressed with TRPV1 on -sensitive nociceptors. |
6(0,0,1,1) | Details |
| 19371406 | Forster AB, Reeh PW, Messlinger K, Fischer MJ: High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors. Mol Pain. 2009 Apr 16;5:17. RESULTS: Morphine induced release of calcitonin gene-related peptide and sensitized the release evoked by heat or the TRPA1 agonist acrolein. |
5(0,0,0,5) | Details |
| 15601931 | Dinis P, Charrua A, Avelino A, Yaqoob M, Bevan S, Nagy I, Cruz F: -evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci. 2004 Dec 15;24(50):11253-63. |
4(0,0,0,4) | Details |
| 18838811 | Iwasaki Y, Tanabe M, Kobata K, Watanabe T: TRPA1 agonists-- and --induce secretion. Biosci Biotechnol Biochem. 2008 Oct;72(10):2608-14. Epub 2008 Oct 7. Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated by the pungent compounds present in spices. |
3(0,0,0,3) | Details |
| 19845671 | Andre E, Gatti R, Trevisani M, Preti D, Baraldi PG, Patacchini R, Geppetti P: Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol. 2009 Nov;158(6):1621-8. Epub 2009 Oct 20. BACKGROUND AND PURPOSE: The transient receptor potential ankyrin receptor 1 (TRPA1) is a cation channel, co-expressed with the pro-tussive transient receptor potential vanilloid type 1 (TRPV1) channel in primary sensory neurons. Acrolein and crotonaldehyde, two alpha,beta-unsaturated aldehydes recently identified as TRPA1 stimulants and contained in cigarette smoke, air pollution or produced endogenously by oxidative stress, caused a remarkable tussive effect, a response that was selectively inhibited by HC-030031. |
2(0,0,0,2) | Details |
| 16725114 | Andrade EL, Ferreira J, Andre E, Calixto JB: Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol. 2006 Jun 28;72(1):104-14. Epub 2006 Apr 25. Here we show that vanilloid receptor (TRPV1) stimulation with and activation of TRPA1 with or cause a graded contraction of the rat urinary bladder in vitro. |
2(0,0,0,2) | Details |
| 17344381 | Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M: Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. J Neurosci. 2007 Mar 7;27(10):2435-43. Responses to and were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected. |
2(0,0,0,2) | Details |
| 18468780 | Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P: Transient receptor potential A1 (TRPA1) activity in the human urethra--evidence for a functional role for TRPA1 in the outflow region. Eur Urol. 2009 Mar;55(3):696-704. Epub 2008 Apr 30. In the urothelium, TRPV1 was located to the outer layers whereas TRPA1 was observed in basal urothelial cells. |
2(0,0,0,2) | Details |
| 15193774 | Symanowicz PT, Gianutsos G, Morris JB: Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouse. Neurosci Lett. 2004 May 20;362(2):150-3. The vanilloid receptor (TRPV1) is expressed on sensory C fibers. The current experiments were aimed at examining the role of this receptor in mediating responses to several airborne irritants including an acidic electrophilic (acrolein), and lipophilic solvent (styrene) vapor. |
2(0,0,0,2) | Details |
| 20021572 | Cahusac PM: Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle. J Peripher Nerv Syst. 2009 Dec;14(4):300-9. These results rule out any role for TRPA1 and TRPV1 channels in mechanotransduction processes of slowly adapting type II mechanoreceptors. |
1(0,0,0,1) | Details |
| 18307678 | Geppetti P, Nassini R, Materazzi S, Benemei S: The concept of neurogenic inflammation. BJU Int. 2008 Mar;101 Suppl 3:2-6. ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals. Involvement of the TRP cation channel, subfamily A, member 1 (TRPA1) has also been reported in models of neurogenic inflammation and nociception promoted by the cyclophosphamide metabolite, acrolein. |
1(0,0,0,1) | Details |
| 15046718 | Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. The natural compounds and activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. |
1(0,0,0,1) | Details |