Protein Information

Name NF kappa B
Synonyms DNA binding factor KBF1; EBP 1; KBF 1; KBF1; NF kappa B; NFKB p105; NFKB p50; NFKB 1…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
18266977 Gunther M, Wagner E, Ogris M: Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy?. J Cell Mol Med. 2008 Dec;12(6B):2704-16. Epub 2008 Feb 4.

Further on, acrolein treatment of primary endothelial cells modified NF-(kappa) B activity levels.
81(1,1,1,1) Details
10966506 Kehrer JP, Biswal SS: The molecular effects of acrolein. . Toxicol Sci. 2000 Sep;57(1):6-15.

It is apparent that the activation of the transcription factors nuclear factor kappa B (NF-kappa B) and activator protein 1 (AP-1) can be inhibited by acrolein.
31(0,1,1,1) Details
18798499 Xu ZB, Feng YL, Xiao J, Tang YJ, Qiu T: [Interventions of enalapril on airway inflammation in rat models induced by acrolein]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;39(4):583-7.

CONCLUSION: Acrolein inhalation could upregulate the expression of Ang II and NF-kappa B and also increase nuclear translocation ratio of NF-kappa B.
8(0,0,1,3) Details
15710356 Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, Oh KW, Han DC, Kwon BM, Hong JT: Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol. 2005 Mar 1;69(5):791-9. Epub 2005 Jan 16.

2(0,0,0,2) Details
18972840 Pokharel YR, Yoon SY, Kim SK, Li JD, Kang KW: Inhibition of acrolein-stimulated MUC5AC production by fucoidan in human bronchial epithelial cells. Pharmazie. 2008 Oct;63(10):757-9.

The activation of both nuclear factor-kappa B (NF-kappa B) and activator protein 1 (AP-1) are key steps in the transcriptional activation of MUC5AC.
1(0,0,0,1) Details