| Name | gamma glutamylcysteine synthetase |
|---|---|
| Synonyms | GCLM; GCS light chain; GLCLR; Gamma ECS; Gamma glutamylcysteine synthetase; Gamma glutamylcysteine synthetase regulatory subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory subunit… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17178418 | King AA, Shaughnessy DT, Mure K, Leszczynska J, Ward WO, Umbach DM, Xu Z, Ducharme D, Taylor JA, Demarini DM, Klein CB: Antimutagenicity of and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. Mutat Res. 2007 Mar 1;616(1-2):60-9. Epub 2006 Dec 18. RT-PCR results paralleled the Affymetrix results for four selected genes (HMOX1, DDIT4, GCLM, and CLK4). |
1(0,0,0,1) | Details |
| 7597707 | Misra P, Srivastava SK, Singhal SS, Awasthi S, Awasthi YC, Boor PJ: Glutathione S-transferase 8-8 is localized in smooth muscle cells of rat aorta and is induced in an experimental model of atherosclerosis. Toxicol Appl Pharmacol. 1995 Jul;133(1):27-33. A significant increase in gamma-glutamylcysteine synthetase activity and GST activity toward and acrolein, which are preferred substrates of GST8-8, was seen as early as 3 days following AA treatment. |
31(0,1,1,1) | Details |
| 19651797 | Zhang H, Forman HJ: Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicol Ind Health. 2009 May-Jun;25(4-5):269-78. Two electrophiles, (HNE) and acrolein, induced the expression of phase II genes (GCLC, GCLM, NQO1, NQO2, HO-1, and GSTM-1). |
6(0,0,1,1) | Details |
| 19633057 | Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M, Hayes JD: 1--2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated acrolein. Carcinogenesis. 2009 Oct;30(10):1754-62. Epub 2009 Jul 24. In rat liver RL-34 epithelial cells, 1-cyano-2,3-epithiopropane (CETP), 1-cyano-3,4-epithiobutane (CETB) and 1-cyano-4,5-epithiopentane (CETPent) were shown to induce cytoprotective enzymes including NAD (P) H:quinone oxidoreductase 1 (NQO1), glutathione (GSH) S-transferase A3 and the glutamate-cysteine ligase modifier subunit; CETP was more potent in this regard than were either CETB or CETPent, with 50 microM CETP eliciting a remarkable approximately 10-fold induction of NQO1. |
1(0,0,0,1) | Details |
| 12084617 | Tirumalai R, Rajesh Kumar T, Mai KH, Biswal S: Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett. 2002 Jun 7;132(1):27-36. Exposure of human type II lung epithelial (A549) cells to non-lethal dose of acrolein (150 fmol/cell for 1 h) depletes 80% of intracellular and increases the transcription of gamma-glutamylcysteine synthetase (gamma-GCS) at 6-12 h post-treatment, which helps in replenishing the to normal level. |
6(0,0,1,1) | Details |
| 12535742 | Cao Z, Hardej D, Trombetta LD, Trush MA, Li Y: Induction of cellular and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity. Atherosclerosis. 2003 Feb;166(2):291-301. Treatment of A10 cells with D3T also led to induction of gamma-glutamylcysteine synthetase, the key enzyme involved in GSH biosynthesis. |
1(0,0,0,1) | Details |