| Name | protein disulfide isomerase |
|---|---|
| Synonyms | Cellular thyroid hormone binding protein p55; P55; Cellular thyroid hormone binding protein; DSI; ERBA2L; GIT; Glutathione insulin transhydrogenase; P4HB… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19271284 | Chung WG, Miranda CL, Stevens JF, Maier CS: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive species. Food Chem Toxicol. 2009 Apr;47(4):827-36. Mass spectrometry-based proteomic analysis in combination with 2-alkenal-specific immunochemical detection identified beta-actin and protein disulfide isomerase as major putative targets of acrolein adduction. |
81(1,1,1,1) | Details |
| 19709606 | Chung WG, Miranda CL, Stevens JF, Maier CS: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive species. Food Chem Toxicol. 2009 Jan 15. Mass spectrometry-based proteomic analysis in combination with 2-alkenal-specific immunochemical detection identified beta-actin and protein disulfide isomerase as major putative targets of acrolein adduction. |
81(1,1,1,1) | Details |
| 15318812 | Liu XW, Sok DE: Inactivation of protein disulfide isomerase by alkylators including alpha,beta-unsaturated aldehydes at low physiological pHs. Biol Chem. 2004 Jul;385(7):633-7. In addition, PDIred was found to be inactivated by acrolein (IC50=10 microM) at pH 6.3, and this inactivation was also greater at pH 6.3 than at pH 7. |
2(0,0,0,2) | Details |
| 16097806 | Carbone DL, Doorn JA, Kiebler Z, Petersen DR: modification by lipid peroxidation products inhibits protein disulfide isomerase. Chem Res Toxicol. 2005 Aug;18(8):1324-31. Similar treatments with the lipid peroxidation products acrolein (ACR) and 4-oxononenal (4-ONE) resulted in 60 and 100% inhibition, respectively, suggesting inactivation of the chaperone via Cys modification. |
2(0,0,0,2) | Details |