| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2451997 | Pickel VM, Joh TH, Chan J: Substance P in the rat nucleus accumbens: ultrastructural localization in axon terminals and their relation to dopaminergic afferents. Brain Res. 1988 Mar 22;444(2):247-64. Coronal vibratome sections from acrolein-fixed brains were sequentially processed for the localization of: (1) a rat monoclonal antiserum against SP identified by the peroxidase--anti-peroxidase immunocytochemical method, and (2) a rabbit polyclonal antiserum against tyrosine hydroxylase (TH) identified by immunoautoradiography. |
3(0,0,0,3) | Details |
| 14615858 | Richardson KA, Gatti PJ: Genioglossal hypoglossal motoneurons contact substance P-like immunoreactive nerve terminals in the cat: a dual labeling electron microscopic study. Exp Brain Res. 2004 Feb;154(3):327-32. Epub 2003 Nov 13. Two days later, the animals were perfused with acrolein fixative. |
2(0,0,0,2) | Details |
| 9950884 | Robledo RF, Witten ML: NK1-receptor activation prevents hydrocarbon-induced lung injury in mice. Am J Physiol. 1999 Feb;276(2 Pt 1):L229-38. Recent evidence suggests that neurokinin (NK)-receptor activation may have a protective role in maintaining lung integrity when challenged by airborne toxicants such as dioxide, ozone, acrolein, or hydrocarbons. Mice administered [Sar9,Met (O2) 11] substance P, an NK1-receptor agonist, after each JP-8 exposure had the appearance of normal pulmonary values and tissue morphology. |
1(0,0,0,1) | Details |
| 19507004 | Doihara H, Nozawa K, Kojima R, Kawabata-Shoda E, Yokoyama T, Ito H: QGP-1 cells release via TRPA1 activation; a model of human enterochromaffin cells. Mol Cell Biochem. 2009 Nov;331(1-2):239-45. Epub 2009 Jun 9. In this study, QGP-1 cells, a human pancreatic endocrine cell line, were found to highly express TRPA1 and EC cell marker genes, such as tryptophan hydroxylase 1 (TPH1), chromogranin A (CgA), synaptophysin, ATP-dependent vesicular monoamine transporter 1 (VMAT1), metabotropic glutamate receptor 4 (mGluR4), beta1-adrenergic receptor (ADB1), muscarinic 4 acetylcholine receptor (ACM4), substance P, serotonin transporter (SERT), and guanylin. Furthermore, the TRPA1 agonists AITC, CA, and acrolein concentration dependently evoked an increase in intracellular Ca (2+) influx and the release of in QGP-1 cells. |
1(0,0,0,1) | Details |
| 9503382 | Kiss J, Csaki A, Bokor H, Kocsis K, Szeiffert G: Topographic localization of calretinin, calbindin, VIP, substance P, CCK and metabotropic glutamate receptor immunoreactive neurons in the supramammillary and related areas of the rat. Neurobiology. 1997;5(3):361-88. The following experiments were performed: (a) immunocytochemistry for each of the eight different neuropeptides investigated, in animals pretreated or not with colchicine, and perfused in fixative containing or lacking acrolein; (b) a thorough mapping study of the localization of immunolabelled neurons at three rostrocaudal levels; (c) double-tracing retrograde labelling for two-directional neuronal projections combined with immunocytochemistry, to study neurochemical character of the projecting neurons. |
1(0,0,0,1) | Details |
| 18307678 | Geppetti P, Nassini R, Materazzi S, Benemei S: The concept of neurogenic inflammation. BJU Int. 2008 Mar;101 Suppl 3:2-6. Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons and the subsequent release of inflammatory neuropeptides, including substance P and calcitonin gene-related peptide. Involvement of the TRP cation channel, subfamily A, member 1 (TRPA1) has also been reported in models of neurogenic inflammation and nociception promoted by the cyclophosphamide metabolite, acrolein. |
1(0,0,0,1) | Details |
| 16725114 | Andrade EL, Ferreira J, Andre E, Calixto JB: Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol. 2006 Jun 28;72(1):104-14. Epub 2006 Apr 25. The exposure of urinary bladders to (100 microM) causes an increase in the (2) and substance P levels. |
1(0,0,0,1) | Details |
| 2422251 | Pickel VM, Chan J, Milner TA: Autoradiographic detection of [125I]-secondary antiserum: a sensitive light and electron microscopic labeling method compatible with peroxidase immunocytochemistry for dual localization of neuronal antigens. J Histochem Cytochem. 1986 Jun;34(6):707-18. Adult rat brains were fixed by aortic arch perfusion with acrolein and paraformaldehyde. These sections were then directly processed for autoradiography or were incubated with rabbit antiserum to substance P (SP) or [Met5]-enkephalin (ME). |
1(0,0,0,1) | Details |
| 1370598 | Zayasu K, Ohrui T, Sekizawa K, Yamaya M, Fukushima T, Sasaki H, Takishima T: desensitization inhibits cigarette smoke-induced increase in cytoplasmic motility of alveolar macrophages in guinea pigs. Am Rev Respir Dis. 1992 Jan;145(1):197-202. Acrolein decreased lambda 0 in animals with and without However, substance P (SP) increased lambda 0, and repeated administration of SP produced a significant tachyphylaxis in animals with and without pretreatment in a fashion similar to that noted with cigarette smoke inhalation. |
1(0,0,0,1) | Details |
| 10562632 | Morris JB, Stanek J, Gianutsos G: Sensory nerve-mediated immediate nasal responses to inspired acrolein. . J Appl Physiol. 1999 Nov;87(5):1877-86. |
0(0,0,0,0) | Details |
| 19418724 | Linares-Fernandez B, Alfieri AB: [Changes in prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. Invest Clin. 2009 Mar;50(1):23-33. |
0(0,0,0,0) | Details |
| 7685755 | Turner CR, Stow RB, Hubbs SJ, Gomes BC, Williams JC: Acrolein increases airway sensitivity to substance P and decreases NEP activity in guinea pigs. J Appl Physiol. 1993 Apr;74(4):1830-9. Experiments performed in the presence of thiorphan suggested that the acrolein-induced reduction in NEP may contribute to increased airway sensitivity to aerosolized substance P, but the increase in airway sensitivity to intravenous substance P may occur by additional mechanisms. |
99(1,1,4,4) | Details |
| 17950047 | Hazari MS, Rowan WH, Winsett DW, Ledbetter AD, Haykal-Coates N, Watkinson WP, Costa DL: Potentiation of pulmonary reflex response to 24h following whole-body acrolein exposure is mediated by TRPV1. Respir Physiol Neurobiol. 2008 Feb 1;160(2):160-71. Epub 2007 Sep 15. These data suggest that although potentiation of pulmonary chemoreflex response 24h post-acrolein is mediated by TRPV1 and release of substance P, cardiopulmonary inhibition during whole-body acrolein exposure is mediated through other mechanisms. |
82(1,1,1,2) | Details |
| 8032584 | Ahluwalia A, Maggi CA, Santicioli P, Lecci A, Giuliani S: Characterization of the -sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder. Br J Pharmacol. 1994 Apr;111(4):1017-22. The effect of acrolein in vitro was significantly reduced by pretreatment of the bladder with a combination of tachykinin NK1 and NK2 receptor antagonists, RP 67,580 (3 microM) and SR 48,968 (1 microM). |
31(0,1,1,1) | Details |
| 19028774 | Faroon O, Roney N, Taylor J, Ashizawa A, Lumpkin MH, Plewak DJ: Acrolein health effects. Toxicol Ind Health. 2008 Aug;24(7):447-90. Levels of acrolein between 22 and 249 ppm for 10 min induced a dose-related decrease in substance P (a short-chain polypeptide that functions as a neurotransmitter or neuromodulator). |
31(0,1,1,1) | Details |
| 7534773 | Van Bockstaele EJ, Gracy KN, Pickel VM: Dynorphin-immunoreactive neurons in the rat nucleus accumbens: ultrastructure and synaptic input from terminals containing substance P and/or dynorphin. J Comp Neurol. 1995 Jan 2;351(1):117-33. We examined the immunogold-silver localization of dynorphin and immunoperoxidase labeling for substance P in single coronal sections through the core subregion of the nucleus accumbens of acrolein-fixed rat brain tissue. |
15(0,0,1,10) | Details |
| 1696540 | Springall DR, Edginton JA, Price PN, Swanston DW, Noel C, Bloom SR, Polak JM: Acrolein depletes the neuropeptides CGRP and substance P in sensory nerves in rat respiratory tract. Environ Health Perspect. 1990 Apr;85:151-7. |
13(0,0,2,3) | Details |
| 9214539 | Borhegyi Z, Leranth C: Substance P innervation of the rat hippocampal formation. J Comp Neurol. 1997 Jul 21;384(1):41-58. Light and electron microscopic substance P (SP) immunostaining was performed on hippocampal sections of colchicine-pretreated, control, untreated fimbria-fornix-transected (5 days), as well as perforant path-stimulated Sprague-Dawley rats fixed in 5% acrolein. |
7(0,0,1,2) | Details |
| 8306034 | Ben-Jebria A, Marthan R, Rossetti M, Savineau JP, Ultman JS: Human bronchial smooth muscle responsiveness after in vitro exposure to acrolein. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):382-6. The effect of acrolein exposure on human bronchial smooth muscle was also assessed by examining the contractile responses to potassium chloride (KCl), and neurokinin A (NKA) in both the absence and the presence of phosphoramidon. |
6(0,0,1,1) | Details |
| 7510277 | Turner CR, Stow RB, Talerico SD, Christian EP, Williams JC: Protective role for neuropeptides in acute pulmonary response to acrolein in guinea pigs. J Appl Physiol. 1993 Dec;75(6):2456-65. To determine the potential role of neuropeptides in acrolein-induced airway responses, -treated guinea pigs were exposed to acrolein aerosol in a regimen causing increased airway sensitivity to substance P. |
6(0,0,1,1) | Details |
| 17684094 | Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P: an endogenous causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. Epub 2007 Aug 7. TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent somatosensory neurons that contain substance P and calcitonin gene-related peptide. Environmental irritants such as mustard oil, allicin, and acrolein activate TRPA1, causing acute pain, neuropeptide release, and neurogenic inflammation. |
2(0,0,0,2) | Details |