Protein Information

Name NK1
Synonyms BY55; CD160; CD160 antigen; CD160 antigen precursor; CD160 molecule; NK1; NK28; Natural killer cell receptor BY55…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
8032584 Ahluwalia A, Maggi CA, Santicioli P, Lecci A, Giuliani S: Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder. Br J Pharmacol. 1994 Apr;111(4):1017-22.

The effect of acrolein in vitro was significantly reduced by pretreatment of the bladder with a combination of tachykinin NK1 and NK2 receptor antagonists, RP 67,580 (3 microM) and SR 48,968 (1 microM).
82(1,1,1,2) Details
9950884 Robledo RF, Witten ML: NK1-receptor activation prevents hydrocarbon-induced lung injury in mice. Am J Physiol. 1999 Feb;276(2 Pt 1):L229-38.

Recent evidence suggests that neurokinin (NK)-receptor activation may have a protective role in maintaining lung integrity when challenged by airborne toxicants such as sulfur dioxide, ozone, acrolein, or hydrocarbons.
5(0,0,0,5) Details
19418724 Linares-Fernandez B, Alfieri AB: [Changes in nitric oxide, prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. Invest Clin. 2009 Mar;50(1):23-33.

ACR-induced mortality was partially prevented by WIN (NK1 antagonist) and MITU (iNOS inhibitor).
1(0,0,0,1) Details