Protein Information

Name protein tyrosine phosphatases
Synonyms DUSP16; DUSP16 protein; Dual specificity phosphatase 16; Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase 7; MKP 7; MKP7…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
12186556 Fu H, Park J, Pei D: Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases. Biochemistry. 2002 Aug 27;41(34):10700-9.

2(0,0,0,2) Details
17655273 Seiner DR, LaButti JN, Gates KS: Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein. Chem Res Toxicol. 2007 Sep;20(9):1315-20. Epub 2007 Jul 27.

0(0,0,0,0) Details
16930132 Hao Q, Maret W: Aldehydes release zinc from proteins. FEBS J. 2006 Sep;273(18):4300-10. Epub 2006 Aug 23.

Thus both acetaldehyde and acrolein induce the expression of metallothionein and modulate protein tyrosine phosphatase activity in a zinc-dependent way.
81(1,1,1,1) Details