| Name | MMP9 |
|---|---|
| Synonyms | 92 kDa gelatinase; Neutrophil collagenase; 92 kDa type IV collagenase; CLG4B; Collagenase type IV B; Collagenase type V; GEL B; GELB… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15531749 | Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, Nadel JA, Leikauf GD: Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med. 2005 Feb 15;171(4):305-14. Epub 2004 Nov 5. Small, interfering RNA directed against ADAM17 or MMP9 inhibited the acrolein-induced MUC5AC mRNA increase. |
305(3,5,5,5) | Details |
| 18006877 | Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD: Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54. Epub 2007 Nov 15. |
149(1,3,4,4) | Details |
| 19661247 | Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD: Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. Epub 2009 Aug 6. Previously, we reported that acrolein levels found in COPD sputum could activate matrix metalloproteinase-9 (MMP9). |
81(1,1,1,1) | Details |
| 20153347 | Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU, Bae SS, Kim CD: Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Toxicol Appl Pharmacol. 2010 Feb 11. Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction, and 5-lipoxygenase (5-LO) is involved in the production of matrix metalloproteinase-9 (MMP-9), which destabilizes atherosclerotic plaques. |
31(0,1,1,1) | Details |
| 17950725 | Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD: CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol. 2007 Dec;83(3):301-10. Epub 2007 Sep 26. METHODS: We analyzed pulmonary inflammation and alveolar destruction in wild-type and Cd8-deficient mice chronically exposed to acrolein, a potent respiratory tract irritant. The expression of several inflammatory cytokines (IP-10, IFN-gamma, IL-12, RANTES, and MCP-1), MMP2 and MMP9 gelatinase activity, and caspase3 immunoreactivity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice compared to wild-type. |
1(0,0,0,1) | Details |
| 19631294 | Liu DS, Wang T, Han SX, Dong JJ, Liao ZL, He GM, Chen L, Chen YJ, Xu D, Hou Y, Li YP, Wen FQ: p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog. Int Immunopharmacol. 2009 Sep;9(10):1228-35. Epub 2009 Jul 22. OBJECTIVE: To evaluate the role of p38 mitogen-activated protein kinase (MAPK) on mice airway inflammation, mucus production and the possible cross-talk between p38 MAPK and matrix metalloproteinase-9 (MMP-9) in mucin protein synthesis. |
1(0,0,0,1) | Details |