| Name | glyceraldehyde 3 phosphate dehydrogenase |
|---|---|
| Synonyms | CDABP0047; G3PD; GAPD; GAPD protein; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; GAPD proteins; Glyceraldehyde 3 phosphate dehydrogenases |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12032148 | Furuhata A, Nakamura M, Osawa T, Uchida K: Thiolation of protein-bound carcinogenic J Biol Chem. 2002 Aug 2;277(31):27919-26. Epub 2002 May 24. The FDP- adduct generated in the acrolein-modified protein was suggested to represent a thiol-reactive electrophile based on the following observations. (i) N (alpha)-acetyl-FDP- prepared from the reaction of N (alpha)-acetyl with acrolein, was covalently bound to glyceraldehyde-3-phosphate dehydrogenase. (ii) The FDP- derivative reacted with to form a GSH conjugate. (iii) The acrolein-modified bovine serum albumin significantly reacted with GSH to form a glutathiolated protein. |
112(1,2,2,2) | Details |
| 12921788 | Al-Maghrebi MA, Al-Mulla F, Benov LT: induces apoptosis in a human breast cancer cell line. Arch Biochem Biophys. 2003 Sep 1;417(1):123-7. Activated phagocytes employ myeloperoxidase to generate and acrolein. Using breast cancer cells, we demonstrate that inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. |
1(0,0,0,1) | Details |
| 3862614 | Green GM: Mechanisms of tobacco smoke toxicity on pulmonary macrophage cells. Eur J Respir Dis Suppl. 1985;139:82-5. The filtered gas phase of cigarette smoke or acrolein suppresses phagocytic uptake and intracellular digestion of staphylococci when exposed in vitro; produces marked morphologic changes in the cytoplasmic membrane; inhibits cellular adhesion; disturbs glycolysis and arachidonic metabolism; inhibits and ATPase, glyceraldehyde 3-phosphate dehydrogenase, and probably endoperoxide E-isomerase, but not and ATPase, glucose 6-phosphate dehydrogenase or lactic dehydrogenase in a dose-response fashion. |
0(0,0,0,0) | Details |
| 19578873 | Mano J, Miyatake F, Hiraoka E, Tamoi M: Evaluation of the toxicity of stress-related aldehydes to photosynthesis in chloroplasts. Planta. 2009 Sep;230(4):639-48. Epub 2009 Jul 4. In the acrolein-treated chloroplasts, the Calvin cycle enzymes phosphoribulokinase, glyceraldehyde-3-phosphate dehydrogenase, -1,6-bisphophatase, -1,7-bisphosphatase, aldolase, and Rubisco were irreversibly inactivated. |
31(0,1,1,1) | Details |