| Name | ALDH 3 |
|---|---|
| Synonyms | ALDH class 3; ALDH 3; ALDH3; ALDH3A1; ALDH3A1 protein; ALDHIII; Acetaldehyde dehydrogenase 3; Aldehyde dehydrogenase 3… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9698086 | Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. We found that both ALDH isozymes were inhibited by acrolein, with IC50 values of 35 and 144 microM for ALDH-1 or ALDH-3, respectively. |
31(0,1,1,1) | Details |
| 11306050 | Townsend AJ, Leone-Kabler S, Haynes RL, Wu Y, Szweda L, Bunting KD: Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells. Chem Biol Interact. 2001 Jan 30;130-132(1-3):261-73. Neither ALDH1A1 nor ALDH3A1 conferred any protection against acrolein, or chloroacetaldehyde. We have developed transgenic cell lines to examine the potential for either human ALDH1A1 or ALDH3A1 to protect against damage mediated by these toxic aldehydes. |
6(0,0,0,6) | Details |
| 19224214 | Hingorani P, Zhang W, Piperdi S, Pressman L, Lin J, Gorlick R, Kolb EA: Preclinical activity of palifosfamide (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64(4):733-40. Epub 2009 Feb 18. ALDH1A1 and ALDH3A1 gene expression data for the OS xenografts were mined from the Pediatric Preclinical Testing Program gene expression data. They are pro-drugs and undergo hepatic metabolism into the active moiety and potentially toxic by-products such as acrolein and chloracetaldehyde, which may cause hemorrhagic cystitis and encephalopathy, respectively. |
4(0,0,0,4) | Details |
| 8662659 | Bunting KD, Townsend AJ: Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. J Biol Chem. 1996 May 17;271(20):11891-6. Transfectants were cross-resistant to 4-hydroperoxycyclophosphamide and 4-hydroperoxyifosfamide but not to phosphoramide mustard, ifosfamide mustard, melphalan, or acrolein. Expression of class 3 aldehyde dehydrogenase (ALDH-3) has been associated with acquired or inherent resistance to oxazaphosphorine (OAP) antineoplastic alkylating agents (eg. cyclophosphamide). |
4(0,0,0,4) | Details |