| Name | xanthine oxidase |
|---|---|
| Synonyms | XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8397144 | Adams JD Jr, Klaidman LK: Acrolein-induced radical formation. Free Radic Biol Med. 1993 Aug;15(2):187-93. Acrolein was oxidized by xanthine oxidase to produce acroleinyl radical and O2 (.-). |
82(1,1,1,2) | Details |
| 3100025 | Bernacki RJ, Bansal SK, Gurtoo HL: Combinations of mesna with cyclophosphamide or adriamycin in the treatment of mice with tumors. Cancer Res. 1987 Feb 1;47(3):799-802. Microsomal mixed function oxidases activate cyclophosphamide to produce phosphoramide mustard and acrolein, while cytochrome reductase and xanthine oxidase are capable of transforming Adriamycin and forming free radicals. |
31(0,1,1,1) | Details |
| 18607771 | Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, Li Y: Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol. 2008 Fall;8(3):115-25. Epub 2008 Jul 8. Pretreatment with (0.5, 1, and 5 microM) protected aortic smooth muscle cells from oxidative and electrophilic cytotoxicity induced by xanthine oxidase (XO)/ H2O2, SIN-1-derived and acrolein. |
6(0,0,1,1) | Details |
| 9823547 | Cighetti G, Debiasi S, Ciuffreda P, Allevi P: Beta-ethoxyacrolein contamination increases malondialdehyde inhibition of milk xanthine oxidase activity. Free Radic Biol Med. 1998 Nov 1;25(7):818-25. |
2(0,0,0,2) | Details |
| 3806088 | Mitchell PC: in enzymatic and heterogeneous catalysis. J Inorg Biochem. 1986 Oct-Nov;28(2-3):107-23. Oxomolybdenum (VI) compounds catalyze selective oxidation of unsaturated hydrocarbons, e.g., propene to acrolein. Similarly, oxomolybdenum species take part in reactions catalyzed by molybdoenzymes, e.g., xanthine oxidase, sulfite oxidase, reductase. |
1(0,0,0,1) | Details |
| 16443152 | Muralikrishna Adibhatla R, Hatcher JF: Phospholipase A2, reactive species, and lipid peroxidation in cerebral ischemia. Free Radic Biol Med. 2006 Feb 1;40(3):376-87. Epub 2005 Nov 21. Dissecting the contribution of PLA2 to lipid peroxidation in cerebral ischemia is challenging due to multiple forms of PLA2, hydrolysis, diverse sources of ROS arising from arachidonic acid metabolism, catecholamine autoxidation, xanthine oxidase activity, mitochondrial dysfunction, activated neutrophils coupled with oxidase activity, and lack of specific inhibitors. These two processes contribute to formation of lipid peroxides, which degrade to reactive products (malondialdehyde, and acrolein) that covalently bind to proteins/nucleic acids, altering their function and causing cellular damage. |
1(0,0,0,1) | Details |
| 19368556 | Neumann M, Mittelstadt G, Iobbi-Nivol C, Saggu M, Lendzian F, Hildebrandt P, Leimkuhler S: A periplasmic oxidoreductase represents the first dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli. FEBS J. 2009 May;276(10):2762-74. Epub 2009 Apr 1. Three DNA regions carrying genes encoding putative homologs of xanthine dehydrogenases were identified in Escherichia coli, named xdhABC, xdhD, and yagTSRQ. |
1(0,0,0,1) | Details |
| 8784495 | Johnson WC, Cluff CW, Goff WL, Wyatt CR: Reactive and intermediates and products from polyamine degradation are Babesiacidal in vitro. Ann N Y Acad Sci. 1996 Jul 23;791:136-47. Polyamines are degraded into acrolein which has also been shown to be toxic to Plasmodium spp. degradation by xanthine oxidase leads to the formation of peroxide, and |
1(0,0,0,1) | Details |
| 3978623 | Sladek NE, Landkamer GJ: Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines. Cancer Res. 1985 Apr;45(4):1549-55. The sensitivity of cultured L1210 and P388 cells sensitive (L1210/0, P388/0) and resistant (L1210/OAP, P388/CLA) to oxazaphosphorines, to 4-hydroperoxycyclophosphamide, ASTA Z-7557, phosphoramide mustard, and acrolein was determined in the absence and presence of known (disulfiram, diethyldithiocarbamate, cyanamide) or suspected [ethylphenyl (2-formylethyl) inhibitors of aldehyde dehydrogenase activity. |
0(0,0,0,0) | Details |
| 19371603 | O'Toole TE, Zheng YT, Hellmann J, Conklin DJ, Barski O, Bhatnagar A: Acrolein activates matrix metalloproteinases by increasing reactive species in macrophages. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):194-201. Epub 2009 Feb 7. These observations suggest that acrolein exposure results in MMP secretion from macrophages via a mechanism that involves an increase in [Ca2+](I), leading to xanthine oxidase activation and an increase in ROS production. |
88(1,1,2,3) | Details |