| Name | Raf 1 |
|---|---|
| Synonyms | C RAF; CRAF; Oncogene MIL; Oncogene RAF1; RAF; RAF proto oncogene serine/threonine protein kinase; RAF1; RAF1 protein… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9622079 | Egorin MJ, Rosen DM, Wolff JH, Callery PS, Musser SM, Eiseman JL: Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. Cancer Res. 1998 Jun 1;58(11):2385-96. 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a compound that is proposed for clinical development, shares the ability of geldanamycin to bind to heat shock protein 90 and GRP94, thereby depleting cells of p185erbB2, mutant p53, and Raf-1. These data have implications with regard to preclinical toxicology and activity testing of 17AAG as well as its proposed clinical development because: (a) production of 17AG requires concomitant production of acrolein from the cleaved allyl moiety; and (b) 17AG, which was not metabolized by microsomes, has been described as being as active as 17AAG in decreasing cellular p185erbB2. |
1(0,0,0,1) | Details |
| 17318410 | Sarkar P, Hayes BE: Induction of COX-2 by acrolein in rat lung epithelial cells. . Mol Cell Biochem. 2007 Jul;301(1-2):191-9. Epub 2007 Feb 21. In addition, the upstream signaling cascade involved Raf-1/ERK activation by acrolein in the COX-2 induction and was inhibited by GW5074 (a Ras/Raf-1/ERK inhibitor), thereby providing evidence for the role of this cascade in this process. |
81(1,1,1,1) | Details |