| Name | IkappaBalpha |
|---|---|
| Synonyms | I kappa B alpha; Mad3; IKB alpha; IKBA; IKBalpha; IkappaBalpha; Inhibitor of kappa light chain gene enhancer in B cells alpha; MAD 3… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15650393 | Valacchi G, Pagnin E, Phung A, Nardini M, Schock BC, Cross CE, van der Vliet A: Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acrolein. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):25-31. Studies of nuclear factor-kappaB (NFkappaB) activation, an essential event in IL-8 production, showed decreased TNFalpha-induced NFkappaB activation by acrolein, illustrated by inhibition of nuclear translocation of NFkappaB and reduced IkappaBalpha degradation. |
31(0,1,1,1) | Details |
| 17318410 | Sarkar P, Hayes BE: Induction of COX-2 by acrolein in rat lung epithelial cells. . Mol Cell Biochem. 2007 Jul;301(1-2):191-9. Epub 2007 Feb 21. The activation of NFkappaB by acrolein was induced as a result of degradation of IkappaBalpha over the time of treatment. |
31(0,1,1,1) | Details |
| 9728040 | Zhang J, Patel JM, Block ER: Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells. Am J Physiol. 1998 Sep;275(3 Pt 1):L461-8. Pretreatment with the calpain-specific inhibitor E-64d prevented hypoxia-induced mRNA expression and degradation of IkappaBalpha, as well as translocation of p50 subunit to the nuclear membrane. Specificity of the response to hypoxia was determined by comparing the effects of hypoxic exposure with exposure to oxidants such as (NO2) and (NO), as well as to the sulfhydryl reactive chemical acrolein. |
1(0,0,0,1) | Details |