| Name | brains |
|---|---|
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18804145 | Kaneko K, Hineno A, Yoshida K, Ikeda S: Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice. Neurosci Lett. 2008 Nov 28;446(1):56-8. Epub 2008 Sep 11. Immunohistochemical examination showed that acrolein, one of the products of lipid peroxides, and ubiquitin were more markedly immunoreacted in the brains of rotenone-treated, Cp-deficient mice than in rotenone-untreated, Cp-deficient or rotenone-treated, wild-type mice. |
83(1,1,1,3) | Details |
| 15182885 | Poon HF, Calabrese V, Scapagnini G, Butterfield DA: Free radicals and brain aging. Clin Geriatr Med. 2004 May;20(2):329-59. Also, lipid peroxidation products, such as MDA, HNE, and acrolein, were reported to react with DNA and proteins to produce further damage in aged brains. |
82(1,1,1,2) | Details |
| 11408093 | Pocernich CB, Cardin AL, Racine CL, Lauderback CM, Butterfield DA: elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease. Neurochem Int. 2001 Aug;39(2):141-9. Acrolein is a highly reactive product of lipid peroxidation that is elevated in the brains of persons with AD. |
81(1,1,1,1) | Details |
| 18083715 | LoPachin RM, Barber DS, Gavin T: Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases. Toxicol Sci. 2008 Aug;104(2):235-49. Epub 2007 Dec 13. This is particularly germane to a recent proposal that lipid peroxidation and the subsequent liberation of acrolein and HNE in oxidatively stressed neurons mediate synaptotoxicity in brains of Alzheimer's disease patients. |
81(1,1,1,1) | Details |
| 12045399 | Arlt S, Beisiegel U, Kontush A: Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease. Curr Opin Lipidol. 2002 Jun;13(3):289-94. The brains of patients with Alzheimer's disease contain increased levels of lipid-peroxidation products such as or acrolein, and enhanced lipid peroxidation can also be detected in cerebrospinal fluid and plasma from such patients. |
31(0,1,1,1) | Details |
| 1727695 | Arey BJ, Freeman ME: Activity of oxytocinergic neurons in the paraventricular nucleus mirrors the periodicity of the endogenous stimulatory rhythm regulating prolactin secretion. Endocrinology. 1992 Jan;130(1):126-32. Ovariectomized rats were killed at either 0300, 1200, or 1700 h and brains quickly fixed by perfusion with 2.5% acrolein in 4% paraformaldehyde. |
7(0,0,1,2) | Details |
| 3522922 | Pickel VM, Chan J, Park DH, Joh TH, Milner TA: Ultrastructural localization of phenylethanolamine N-methyltransferase in sensory and motor nuclei of the vagus nerve. J Neurosci Res. 1986;15(4):439-55. Adult rats were anesthetized with Nembutal (50 mg/kg intraperitoneally), and the brains were fixed by vascular perfusion with a solution containing 3.75% acrolein and 2% paraformaldehyde in 0.1 M buffer. |
6(0,0,1,1) | Details |
| 1977960 | Chan J, Aoki C, Pickel VM: Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding. J Neurosci Methods. 1990 Aug;33(2-3):113-27. Vibratome sections were collected from acrolein fixed brains of adult rats. |
6(0,0,1,1) | Details |
| 20176130 | Butterfield DA, Bader Lange ML, Sultana R: Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. Biochim Biophys Acta. 2010 Feb 20. Increased levels of oxidative stress markers including the markers of lipid peroxidation such as acrolein, 4--2-trans-nonenal (HNE), malondialdehyde, etc. are found in brains of AD subjects. |
6(0,0,1,1) | Details |
| 3300846 | Milner TA, Pickel VM, Chan J, Massari VJ, Oertel WH, Park DH, Joh TH, Reis DJ: Phenylethanolamine N-methyltransferase-containing neurons in the rostral ventrolateral medulla. Brain Res. 1987 May 12;411(1):46-57. The brains were fixed by perfusion with 3.75% acrolein and 2.0% paraformaldehyde in buffer. |
6(0,0,1,1) | Details |
| 8221135 | Erskine MS: Mating-induced increases in FOS protein in preoptic area and medial amygdala of cycling female rats. Brain Res Bull. 1993;32(5):447-51. Seventy-five minutes after mating, females were perfused intracardially with 2% paraformaldehyde/2.5% acrolein, and the brains were processed for FOS immunocytochemistry using standard procedures. |
6(0,0,1,1) | Details |
| 1349353 | Pickel VM, Chan J, Sesack SR: Cellular basis for interactions between catecholaminergic afferents and neurons containing Leu-enkephalin-like immunoreactivity in rat caudate-putamen nuclei. J Neurosci Res. 1992 Feb;31(2):212-30. These animals were given intraventricular injections of colchicine, and the brains were fixed by acrolein perfusion prior to immunocytochemical labeling. |
6(0,0,1,1) | Details |
| 7787241 | Branchereau P, Van Bockstaele EJ, Chan J, Pickel VM: Ultrastructural characterization of neurons recorded intracellularly in vivo and injected with lucifer yellow: advantages of immunogold-silver vs. immunoperoxidase labeling. Microsc Res Tech. 1995 Apr 1;30(5):427-36. The brains were then perfused with an acrolein fixative. |
6(0,0,1,1) | Details |
| 3300845 | Milner TA, Pickel VM, Park DH, Joh TH, Reis DJ: Phenylethanolamine N-methyltransferase-containing neurons in the rostral ventrolateral medulla of the rat. Brain Res. 1987 May 12;411(1):28-45. The brains were fixed by perfusion with 3.75% acrolein and 2.0% paraformaldehyde in buffer. |
6(0,0,1,1) | Details |
| 8834400 | Pickel VM, Heras A: Ultrastructural localization of calbindin-D28k and in the matrix compartment of the rat caudate-putamen nuclei. Neuroscience. 1996 Mar;71(1):167-78. Sections of striatal tissue from acrolein-fixed adult rat brains were dual-labeled using immunoperoxidase for the localization of rabbit anti-calbindin and immunogold-silver for the localization of rat anti- antibodies. |
6(0,0,1,1) | Details |
| 2422251 | Pickel VM, Chan J, Milner TA: Autoradiographic detection of [125I]-secondary antiserum: a sensitive light and electron microscopic labeling method compatible with peroxidase immunocytochemistry for dual localization of neuronal antigens. J Histochem Cytochem. 1986 Jun;34(6):707-18. Adult rat brains were fixed by aortic arch perfusion with acrolein and paraformaldehyde. |
6(0,0,1,1) | Details |
| 2875140 | Milner TA, Joh TH, Pickel VM: Tyrosine hydroxylase in the rat parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity. J Neurosci. 1986 Sep;6(9):2585-603. In the first portion of the study, a rabbit antiserum to TH was immunocytochemically localized in coronal sections through the lateral PBR from acrolein-fixed brains using the peroxidase-antiperoxidase method. |
6(0,0,1,1) | Details |
| 1354605 | Horvath TL, Naftolin F, Leranth C: Beta-endorphin innervation of neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology. 1992 Sep;131(3):1547-55. Light and electron microscopic double immunostaining experiments were performed on vibratome sections prepared from the hypothalamus of acrolein-fixed female rat brains. |
6(0,0,1,1) | Details |
| 2451997 | Pickel VM, Joh TH, Chan J: Substance P in the rat nucleus accumbens: ultrastructural localization in axon terminals and their relation to dopaminergic afferents. Brain Res. 1988 Mar 22;444(2):247-64. Coronal vibratome sections from acrolein-fixed brains were sequentially processed for the localization of: (1) a rat monoclonal antiserum against SP identified by the peroxidase--anti-peroxidase immunocytochemical method, and (2) a rabbit polyclonal antiserum against tyrosine hydroxylase (TH) identified by immunoautoradiography. |
6(0,0,1,1) | Details |
| 3018192 | Pickel VM, Chan J, Ganten D: Dual peroxidase and colloidal gold-labeling study of angiotensin converting enzyme and angiotensin-like immunoreactivity in the rat subfornical organ. J Neurosci. 1986 Aug;6(8):2457-69. Brains from adult rats were fixed by vascular perfusion with 3.75% acrolein and 2% paraformaldehyde. |
6(0,0,1,1) | Details |
| 7925620 | Shinoda M, Ishikawa K, Miura T: Morphological changes of somatostatin neurons in the suprachiasmatic nucleus by hypophysectomy of the rat. Jikken Dobutsu. 1994 Jul;43(3):333-41. Their brains were fixed by acrolein perfusion at 10, 30 and 60 days after the operation, and then (AVP)-, vasoactive intestinal polypeptide (VIP)- and somatostatin (SRIH)- neurons in the SCN were stained immunohistochemically. |
6(0,0,1,1) | Details |
| 3522659 | Milner TA, Pickel VM: Neurotensin in the rat parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity. J Comp Neurol. 1986 May 15;247(3):326-43. The brains from untreated adult male rats and from others that received intraventricular injections of colchicine (100 micrograms/7.5 microliters saline) 24 hours prior to death were fixed by perfusion with acrolein or glutaraldehyde and paraformaldehyde. |
6(0,0,1,1) | Details |
| 1687805 | D'Costa A, Breese CR, Boyd RL, Booze RM, Sonntag WE: Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice. Brain Res. 1991 Dec 20;567(2):204-11. Animals were anesthetized and perfused intracardially with 2.5% acrolein, 4% paraformaldehyde at 0.5, 1.0, 2.0 and 4.0 h postshock. |
2(0,0,0,2) | Details |
| 1970505 | Smith MW 3rd, Cooper TR, Joh TH, Smith DE: Cell loss and class distribution of TH-I cells in the substantia nigra of the neurological mutant, weaver. Brain Res. 1990 Mar 5;510(2):242-50. Eight-week-old homozygous weaver mutant mice and littermate wildtype controls were perfused with a buffered acrolein and paraformaldehyde solution. The brains were subsequently removed, blocked and sectioned on a vibratome. |
1(0,0,0,1) | Details |
| 9930749 | Calingasan NY, Uchida K, Gibson GE: Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. J Neurochem. 1999 Feb;72(2):751-6. Lipid peroxidation generates various reactive aldehydes, such as (HNE), which have been detected immunochemically in AD, particularly in neurofibrillary tangles, one of the major diagnostic lesions in AD brains. |
1(0,0,0,1) | Details |