| Name | aldose reductase like |
|---|---|
| Synonyms | AKR1B10; ARP; AKR1B10 protein; AKR1B11; AKR1B12; ALDRLn; ARL 1; ARL1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17329238 | Zu X, Yan R, Robbins S, Krishack PA, Liao DF, Cao D: Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression. Toxicol Sci. 2007 Jun;97(2):562-8. Epub 2007 Feb 27. |
62(0,2,2,2) | Details |
| 17597105 | Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D: Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Int J Cancer. 2007 Nov 15;121(10):2301-6. Recombinant AKR1B10 protein showed strong enzymatic activity to acrolein and crotonaldehyde, with K (m) = 110.1 +/- 12.2 microM and V (max) = 3,122.0 +/- 64.7 nmol/mg protein/min for acrolein and K (m) = 86.7 +/- 14.3 microM and V (max) = 2,647.5 +/- 132.2 nmol/mg protein/min for crotonaldehyde. |
19(0,0,2,9) | Details |
| 19608619 | MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, Hayes JD: Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis. 2009 Sep;30(9):1571-80. Epub 2009 Jul 16. This study also shows that AKR1B10, AKR1C1 and AKR1C2 proteins have potential utility as biomarkers for NRF2 activation in the human. Activation of NRF2, by KEAP1 knockdown, caused a 75% increase in the amount of in HaCaT cells and a 1.4- to 1.6-fold increase in their resistance to the electrophiles acrolein, chlorambucil and cumene hydroperoxide (CuOOH), as well as the redox-cycling agent |
1(0,0,0,1) | Details |