| 8804072 |
Reddy PL, Bhargava HN: Effect of low pH treatment on opioid peptides binding to their receptors and functional coupling of G-proteins to adenylyl cyclase in the rat spinal cord. Peptides. 1996;17(4):625-8.
Because low pH treatment is known to alter the coupling of G-proteins to brain receptors, and little is known about such an effect in the spinal cord, the present study was undertaken to examine whether preincubation of rat spinal cord membranes at low pH (pH 4.5) alters opioid receptor binding characteristics and sodium fluoride (NaF)-stimulated adenylyl cyclase (AC) activity (as a function of G, mediated). [3H][D-Ala2,MePhe4,Gly-ol] enkephalin (DAMGO) and [3H] ethylketocyclazosine (EKC) were used to label mu- and kappa-opioid receptors, respectively. |
31(0,1,1,1) |
Details |