Protein Information

Name aquaporin 2
Synonyms ADH water channel; AQP 2; AQP CD; AQP2; Aquaporin 2; Aquaporin CD; Collecting duct water channel protein; WCH CD…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
18971210 Jensen AM, Bae EH, Fenton RA, Norregaard R, Nielsen S, Kim SW, Frokiaer J: Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.

AT1 receptor blockade attenuated V2R, pS256-AQP2, and G (s) alpha protein downregulation in IM and partially reversed the obstruction-induced inhibition of sodium fluoride- and forskolin-stimulated cAMP generation in inner medullary membrane fractions from BUO rats.
33(0,1,1,3) Details
15579502 Kim SW, Kim JW, Choi KC, Ma SK, Oh Y, Jung JY, Kim J, Lee J: Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney. J Am Soc Nephrol. 2004 Dec;15(12):2998-3005.

The generation of cAMP provoked by arginine vasopressin, sodium fluoride, or forskolin was blunted.
8(0,0,0,8) Details
10760099 Kim SW, Jeon YS, Lee JU, Kang DG, Kook H, Ahn KY, Kim SZ, Cho KW, Kim NH, Han JS, Choi KC: Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats. Kidney Int. 2000 Apr;57(4):1643-50.

Immunohistochemical study also showed a markedly decreased expression of AQP2 in the collecting duct in ARF. cAMP generation in response to arginine vasopressin (AVP) in the kidney was attenuated in ARF, most prominently in the outer medulla. cAMP generation in the outer medulla in response to forskolin was not affected, but sodium fluoride was significantly blunted in ARF.
6(0,0,0,6) Details
11316845 Kim SW, Lee JU, Nah MY, Kang DG, Ahn KY, Lee HS, Choi KC: Cisplatin decreases the abundance of aquaporin water channels in rat kidney. J Am Soc Nephrol. 2001 May;12(5):875-82.

However, the cyclic adenosine monophosphate generation in response to forskolin was not affected, whereas that to sodium fluoride was diminished significantly.
Four d later, the expression of AQP1, AQP2, and AQP3 proteins was determined in the kidney.
4(0,0,0,4) Details
11574818 Kim SW, Yeum CH, Kim S, Oh Y, Choi KC, Lee J: Amphotericin B decreases adenylyl cyclase activity and aquaporin-2 expression in rat kidney. J Lab Clin Med. 2001 Oct;138(4):243-9.

The cAMP generation in response to AVP or sodium fluoride was decreased, whereas that to forskolin was not significantly altered.
3(0,0,0,3) Details
12745716 Yeum CH, Kim SW, Lee SC, Choi KC, Ahn KY, Lee J: Diminished expression of aquaporin water channels in ureteral-obstructed kidney in rats. Scand J Urol Nephrol. 2003;37(2):99-105.

The expression of AQP1 and AQP3 was decreased in the outer medulla and inner medulla. cAMP generation in response to AVP, sodium fluoride or forskolin was greatly decreased.
The expression of AQP2 was also determined by immunohistochemistry.
3(0,0,0,3) Details
11388643 Lee J, Yoo KS, Kang DG, Kim SW, Choi KC: Gentamicin decreases the abundance of aquaporin water channels in rat kidney. Jpn J Pharmacol. 2001 Apr;85(4):391-8.

The expression of AQP2 proteins was significantly decreased in the kidney, in which the cortex was most susceptible, followed by the outer medulla and inner medulla in order.
The cAMP generation in response to arginine vasopressin or sodium fluoride was decreased by gentamicin, while that to forskolin was not significantly altered.
2(0,0,0,2) Details
12208125 Yeum CH, Kim SW, Kim NH, Choi KC, Lee J: Increased expression of aquaporin water channels in hypothyroid rat kidney. Pharmacol Res. 2002 Jul;46(1):85-8.

The expression of aquaporin 2 (AQP2) was significantly increased in the cortex, outer medulla, and inner medulla of the kidney.
The adenylyl cyclase activity provoked by arginine vasopressin (AVP), sodium fluoride, or forskolin was blunted in the hypothyroid kidney, while plasma levels of AVP were not significantly changed.
1(0,0,0,1) Details