Protein Information

Name SnF 2
Synonyms ATP dependent helicase SMARCA4; SNF2LB; SWI 2; SWI2; BAF190; SNF 2; SNF2; BRG 1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
15966883 Paraskevas S, Versteeg PA, Timmerman MF, Van der Velden U, Van der Weijden GA: The effect of a dentifrice and mouth rinse combination containing amine fluoride/stannous fluoride on plaque and gingivitis: a 6-month field study. J Clin Periodontol. 2005 Jul;32(7):757-64.

AIM: To examine the effect of amine fluoride/stannous fluoride (AmF/SnF (2))-containing dentifrice and mouth rinse on plaque formation and gingivitis as compared with habitual oral hygiene procedures with a regular sodium fluoride (NaF) dentifrice.
9(0,0,1,4) Details
17999737 Willumsen T, Solemdal K, Wenaasen M, Ogaard B: Stannous fluoride in dentifrice: an effective anti-plaque agent in the elderly?. Gerodontology. 2007 Dec;24(4):239-43.

OBJECTIVE: The aim of this study was to examine differences in plaque accumulation in elderly patients using two toothpastes, with either 0.2% sodium fluoride (NaF) or 0.4% stannous fluoride (SnF (2)), but otherwise identical.
9(0,0,1,4) Details
12037369 Wefel JS, Stanford CM, Ament DK, Hogan MM, Harless JD, Pfarrer AM, Ramsey LL, Leusch MS, Biesbrock AR: In situ evaluation of sodium hexametaphosphate-containing dentifrices. Caries Res. 2002 Mar-Apr;36(2):122-8.

The purpose of this investigator-blinded, five-treatment, crossover human intraoral study was to evaluate the effects of two experimental dentifrice formulations containing either stannous fluoride (SnF (2)) or sodium fluoride (NaF) packaged with sodium hexametaphosphate in a dual-phase delivery system on demineralization-remineralization using an in situ model system.
8(0,0,1,3) Details
19403228 Wiegand A, Bichsel D, Magalhaes AC, Becker K, Attin T: Effect of sodium, amine and stannous fluoride at the same concentration and different pH on in vitro erosion. J Dent. 2009 Aug;37(8):591-5. Epub 2009 Apr 5.

Each day, the samples were exposed for 120 min to pooled human saliva and subsequently treated with one of the fluoride solutions for 3 min: amine fluoride (AmF, 0.5% and 1% F (-)), sodium fluoride (NaF, 0.5% and 1% F (-)), each at pH 3.9 and 7.0, and stannous fluoride (SnF (2), 0.5% and 1% F (-)), at pH: 3.9.
7(0,0,1,2) Details
15016021 Paraskevas S, Danser MM, Timmerman MF, Van der Velden U, Van der Weijden GA: Effect of a combination of amine/stannous fluoride dentifrice and mouthrinse in periodontal maintenance patients. J Clin Periodontol. 2004 Mar;31(3):177-83.

The patients were randomly divided into two groups: (1). the test group used an AmF/SnF (2) dentifrice and mouthrinse and (2). the control group used a sodium fluoride (NaF)-containing dentifrice and mouthrinse.
7(0,0,1,2) Details
20188238 Artopoulou II, Powers JM, Chambers MS: In vitro staining effects of stannous fluoride and sodium fluoride on ceramic material. J Prosthet Dent. 2010 Mar;103(3):163-9.

All disks were brushed for 3 minutes with a soft-bristle power toothbrush and mild dentifrice (baseline) and were immersed in 1 of the 2 fluoride products (0.4% SnF (2), Gel-Kam Gel, or 1.1% NaF, Prevident 5000) for 10 days (n=20).
5(0,0,0,5) Details
16776765 Young A, Thrane PS, Saxegaard E, Jonski G, Rolla G: Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study. Eur J Oral Sci. 2006 Jun;114(3):180-3.


It has recently been shown that stannous fluoride (SnF (2)), in the form of aqueous solutions and as toothpaste, can reduce the dissolution of enamel in erosive acids in vitro and in situ.
3(0,0,0,3) Details
18410574 Flisfisch S, Meyer J, Meurman JH, Waltimo T: Effects of fluorides on Candida albicans. Oral Dis. 2008 May;14(4):296-301.

RESULTS: MICs of AmF / SnF (2) and CHX varied between 1 and 4 microg ml (-1), whereas those of NaF were 15 000 microg ml (-1).
Minimal inhibitory concentrations (MICs) of sodium fluoride (NaF) and of an amine fluoride / stannous fluoride combination (AmF / SnF2) were determined.
3(0,0,0,3) Details
19321990 Hjortsjo C, Jonski G, Thrane PS, Saxegaard E, Young A: The effects of acidic fluoride solutions on early enamel erosion in vivo. Caries Res. 2009;43(2):126-31. Epub 2009 Mar 24.


SnF (2), TiF (4) and hydrogen fluoride (HF) (all approx. 0.1 M F), HF (0.027, 0.055, 0.082 M F) and neutral NaF solution (0.1 M F) as control were applied to the labial surfaces of the teeth for 1 min (6 ml/min).
3(0,0,0,3) Details
18092200 Hove LH, Holme B, Young A, Tveit AB: The erosion-inhibiting effect of TiF4, SnF2, and NaF solutions on pellicle-covered enamel in vitro. Acta Odontol Scand. 2007 Oct;65(5):259-64.


OBJECTIVE: The aim of this study was to compare the protective effect of TiF (4), SnF (2), and NaF treatment on the development of erosion-like lesions in pellicle-covered human enamel.
3(0,0,0,3) Details
9784495 Gdula DA, Sandaltzopoulos R, Tsukiyama T, Ossipow V, Wu C: Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev. 1998 Oct 15;12(20):3206-16.

The 140-kD NURF subunit, imitation switch (ISWI), is related to the SWI2/SNF2 ATPase.
Inhibition of the pyrophosphatase activity of NURF with sodium fluoride has no significant effect on chromatin remodeling, indicating that these two activities may be biochemically uncoupled.
1(0,0,0,1) Details
18027401 Chambers MS, Fleming TJ, Toth BB, Lemon JC, Craven TE, Bouwsma OJ, Garden AS, Espeland MA, Keene HJ, Martin JW, Sipos T: Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Oral Oncol. 2007 Jan;43(1):98-105.

This pilot study revealed that the IFRS was well-tolerated and safe in this study population associated with minimal complications during the duration of this study and was comparable in efficacy to a SnF (2) gel in preventing caries development.
The intraoral fluoride-releasing system (IFRS) containing a sodium fluoride core is a newly developed, sustained-release, passive drug delivery system that does not require patient involvement except for periodic replacement, thus reducing the effect of patient compliance on its effectiveness in dental caries prevention.
1(0,0,0,1) Details
17097208 Busscher HJ, White DJ, Atema-Smit J, van der Mei HC: Efficacy and mechanisms of non-antibacterial, chemical plaque control by dentifrices--an in vitro study. J Dent. 2007 Apr;35(4):294-301. Epub 2006 Nov 9.


RESULTS: All dentifrice supernates containing SLS were effective in detaching co-adhering bacteria from pellicles surfaces, except in combination with SnF (2).
1(0,0,0,1) Details
16757200 Chambers MS, Mellberg JR, Keene HJ, Bouwsma OJ, Garden AS, Sipos T, Fleming TJ: Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Oral Oncol. 2006 Oct;42(9):946-53. Epub 2006 Jun 6.

This pilot study revealed that the IFRS was well-tolerated and safe in this study population associated with minimal complications during the duration of this study and was comparable in efficacy to a SnF (2) gel in preventing caries development.
The intraoral fluoride-releasing system (IFRS) containing a sodium fluoride core is a newly developed, sustained-release, passive drug delivery system that does not require patient involvement except for periodic replacement, thus reducing the effect of patient compliance on its effectiveness in dental caries prevention.
1(0,0,0,1) Details