Protein Information

Name interleukin 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
9581864 Tokuda H, Kozawa O, Harada A, Uematsu T: Tiludronate inhibits interleukin-6 synthesis in osteoblasts: inhibition of phospholipase D activation in MC3T3-E1 cells. J Cell Biochem. 1998 Jun 1;69(3):252-9.

7(0,0,0,7) Details
10602388 Refsnes M, Becher R, Lag M, Skuland T, Schwarze PE: Fluoride-induced interleukin-6 and interleukin-8 synthesis in human epithelial lung cells. Hum Exp Toxicol. 1999 Nov;18(11):645-52.

In the present study the potential of sodium fluoride (NaF) and HF to induce cytokine response was examined and how these responses are modulated by Al3+ in a human epithelial lung cell line (A549).
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11968002 Hatakeyama D, Kozawa O, Otsuka T, Shibata T, Uematsu T: Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D. J Cell Biochem. 2002;85(3):621-8.

6(0,0,0,6) Details
10376804 Tokuda H, Kozawa O, Harada A, Uematsu T: p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts. Cell Signal. 1999 May;11(5):325-30.

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9885886 Bernardin G, Strosberg AD, Bernard A, Mattei M, Marullo S: Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med. 1998 Dec;24(12):1315-22.

We measured beta-adrenergic receptor (betaAR) number and affinity, and intracellular cAMP content at baseline and after the pharmacological stimulation of each component of the beta-adrenergic complex: betaAR with isoproterenol, Gs-protein with sodium fluoride (NaF), adenylate cyclase with forskolin.
Catecholamine (adrenaline, noradrenaline) and cytokine (TNFalpha, IL-1alpha, IL-1beta, IL-6) serum levels were measured.
1(0,0,0,1) Details
10989278 Kozawa O, Kawamura H, Matsuno H, Uematsu T: p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F (2alpha)-induced phosphoinositide hydrolysis. Cell Signal. 2000 Jul;12(7):447-50.


We previously showed that sphingosine inhibits prostaglandin F (2alpha) (PGF (2alpha))-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells.
1(0,0,0,1) Details
10594545 Arnold R, Rihoux J, Konig W: Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549). Clin Exp Allergy. 1999 Dec;29(12):1681-91.


Confluent epithelial cell monolayer were pre-incubated with cetirizine (0.01 -1.0 micromol/L) for 30 min and afterwards activated with pro-inflammatory cytokines (TNF-alpha IL-1beta, IL-6, IFN-gamma) or different agonists (PMA, NaF, respiratory syncytial virus [RSV]) for 24 h.
1(0,0,0,1) Details
8915775 Kawase T, Oguro A, Orikasa M, Burns DM: Characteristics of NaF-induced differentiation of HL-60 cells. J Bone Miner Res. 1996 Nov;11(11):1676-87.

Similarly, NaF stimulated the production of interleukin 1 alpha (IL-1 alpha), IL-6, and tumor necrosis factor-alpha, and 1,25 (OH) 2D3 again strongly enhanced these effects.
Sodium fluoride (NaF) is known to stimulate osteoblastic bone formation, but little attention has been given to the possibility that NaF also affects bone resorption and the differentiation of osteoclastic progenitor cells.
1(0,0,0,1) Details
9892783 Loftenius A, Andersson B, Butler J, Ekstrand J: Fluoride augments the mitogenic and antigenic response of human blood lymphocytes in vitro. Caries Res. 1999;33(2):148-55.


This was tested by measuring the effect of sodium fluoride (NaF) on cytokine production by human whole blood cells stimulated in vitro.
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