| Name | PP2A |
|---|---|
| Synonyms | PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14710095 | Sugiyama M, Imai A, Furui T, Tamaya T: Membrane-associated serine/threonine protein phosphatase in endometrial cancer. Am J Obstet Gynecol. 2003 Dec;189(6):1666-9. The membrane phosphatase was sensitive to inhibition by okadaic acid and sodium fluoride, characteristics suggestive of PP2A activity. |
36(0,1,1,6) | Details |
| 11494123 | Jaumot M, Hancock JF: Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene. 2001 Jul 5;20(30):3949-58. General serine- phosphatase inhibitors such sodium fluoride, or ss-glycerophosphate and or specific PP1 and PP2A inhibitors including microcystin-LR, protein phosphatase 2A inhibitor I (1) or protein phosphatase inhibitor 2 all abrogate H-Ras and K-Ras dependent Raf-1 activation in vitro. |
34(0,1,1,4) | Details |
| 15075332 | Hashigasako A, Machide M, Nakamura T, Matsumoto K, Nakamura T: Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor. J Biol Chem. 2004 Jun 18;279(25):26445-52. Epub 2004 Apr 9. Likewise, treatment of cells with NaF (an inhibitor of protein phosphatases) allowed for phosphorylation of Ser-985, and a protein phosphatase responsible for dephosphorylation of Ser-985 was identified to be protein phosphatase 2A (PP2A). |
3(0,0,0,3) | Details |
| 16407301 | Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR: Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation. J Biol Chem. 2006 Mar 10;281(10):6236-45. Epub 2006 Jan 9. In addition, phosphorylation of Ser526 was required for MKK6 phosphorylation in vitro, whereas dephosphorylation of Ser526 was mediated by protein phosphatase 2A and sensitive to okadaic acid and sodium fluoride. In summary, Ser526 of MEKK3 is an autophosphorylation site within the T-loop that is regulated by PP2A and 14-3-3 proteins. |
1(0,0,0,1) | Details |
| 9475387 | Eyster KM, Berger TL, Rodrigo MC, Sheth MV: Protein phosphatase activity in the rat ovary throughout pregnancy and pseudopregnancy. Biol Reprod. 1998 Feb;58(2):338-45. Tissues were processed in the presence of sodium fluoride and inorganic to inhibit the phosphatase and thereby prevent autodephosphorylation of the type 2A protein phosphatase (PP2A) during homogenization. |
33(0,1,1,3) | Details |
| 14534713 | Sugiyama M, Imai A, Furui T, Tamaya T: Independent action of serine/threonine protein phosphatase in ovarian cancer plasma membrane and cytosol during gonadotropin-releasing hormone stimulation. Oncol Rep. 2003 Nov-Dec;10(6):1885-9. Reversible serine/ protein phosphorylation catalyzed by kinases and phosphatases 2A (PP2A) plays a crucial role in cellular growth and differentiation. |
7(0,0,0,7) | Details |
| 9245257 | Douglas P, Pigaglio E, Ferrer A, Halfords NG, MacKintosh C: Three spinach leaf reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are required by reversible phosphorylation and/or Ca2+ ions. Biochem J. 1997 Jul 1;325 ( Pt 1):101-9. The Ca2+-independent portion of PKI was inactivated by either PP2A or PP2C, while the Ca2+-dependent portion of PKI became increasingly activated during storage, which we presume was mimicking the effect of an unidentified PP. |
2(0,0,0,2) | Details |