Protein Information

Name PGHS 2
Synonyms COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
19376214 Ridley W, Matsuoka M: Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells. Toxicol Lett. 2009 Aug 10;188(3):180-5. Epub 2009 Apr 17.

To clarify the mechanisms of fluoride-induced airway diseases, we examined the expression of cyclooxygenase-2 (COX-2), an important mediator of airway inflammation, in A549 human pulmonary epithelial cells treated with sodium fluoride (NaF).
7(0,0,1,2) Details
12498919 Adeagbo AS, Patel D, Iddrissu A, Walker J, Thirumalai S, Joshua IG, Schuschke D, Wang Y: NS-398, a selective cyclooxygenase-2 blocker, acutely inhibits receptor-mediated contractions of rat aorta: role of endothelium. Eur J Pharmacol. 2003 Jan 1;458(1-2):145-54.

NS-398 altered contractions to these receptor agonists in denuded rings only at 10 microM, and did not significantly alter contractions to KCl and sodium fluoride in all situations.
5(0,0,0,5) Details
9374663 Rosenstock M, Danon A, Rimon G: Prostaglandin H synthase: protein synthesis-independent regulation in bovine aortic endothelial cells. Am J Physiol. 1997 Nov;273(5 Pt 1):C1749-55.


NS-398 (500 nM), a specific PGHS-2 inhibitor, was ineffective.
1(0,0,0,1) Details