| Name | adenylate cyclase |
|---|---|
| Synonyms | AH related protein; HCA2; ATP pyrophosphate lyase; Adenylate cyclase; Adenylyl cyclase soluble; HCA 2; RP1 313L4.2; SAC… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9885886 | Bernardin G, Strosberg AD, Bernard A, Mattei M, Marullo S: Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med. 1998 Dec;24(12):1315-22. We measured beta-adrenergic receptor (betaAR) number and affinity, and intracellular cAMP content at baseline and after the pharmacological stimulation of each component of the beta-adrenergic complex: betaAR with isoproterenol, Gs-protein with sodium fluoride (NaF), adenylate cyclase with forskolin. |
33(0,1,1,3) | Details |
| 9066384 | Chello M, Mastroroberto P, De Amicis V, Pantaleo D, Ascione R, Spampinato N: Intermittent warm blood cardioplegia preserves myocardial beta-adrenergic receptor function. Ann Thorac Surg. 1997 Mar;63(3):683-8. Moreover, a significant decrease in adenylate cyclase activity during CPB was detected in this group after stimulation with sodium fluoride (p < 0.05), but this pattern was found to be completely reversed by 30 minutes after discontinuation of CPB. |
8(0,0,1,3) | Details |
| 9152774 | Nagami K, Yoshikawa T, Suzuki M, Wainai Y, Anzai T, Handa S: Abnormal beta-adrenergic transmembrane signaling in rabbits with adriamycin-induced cardiomyopathy. Jpn Circ J. 1997 Mar;61(3):249-55. Basal and isoproterenol-, sodium fluoride- and forskolin-stimulated adenylate cyclase activities were lower in the adriamycin-treated group. |
8(0,0,1,3) | Details |
| 9223590 | Gando S, Hattori Y, Akaishi Y, Nishihira J, Kanno M: Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation. J Pharmacol Exp Ther. 1997 Jul;282(1):475-84. The abilities of isoproterenol, sodium fluoride, 5'-guanylyl imidodiphosphate and forskolin to stimulate adenylate cyclase were preserved well in membranes prepared from diabetic hearts. |
7(0,0,1,2) | Details |
| 12081150 | Chang CL, Fung HP: Effects of ketoconazole on and cAMP production in MA-10 mouse Leydig tumor cells. Biol Pharm Bull. 2002 Jun;25(6):794-7. The stimulatory effects of forskolin and sodium fluoride on the adenylate cyclase system were also inhibited by KCZ. |
7(0,0,1,2) | Details |
| 11788863 | Karpenko LG, Gubina NF, Schirova VA, Kaprelyants AS: The effects of freezing and cryoprotectant exposure on adenylate cyclase activity in cell membranes of bovine thyroid gland and adrenal cortex. Cryo Letters. 2001 Jul-Aug;22(4):229-34. |
4(0,0,0,4) | Details |
| 9762710 | Plesneva SA, Nalivaeva NN, Zhuravin IA: Adenylate cyclase system of the rat striatum: regulatory properties and the effects of gangliosides. Neurosci Behav Physiol. 1998 Jul-Aug;28(4):392-6. |
4(0,0,0,4) | Details |
| 11267904 | Chen CH, Gu SH, Chow YS: Adenylate cyclase in prothoracic glands during the last larval instar of the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2001 Apr 27;31(6-7):659-64. |
4(0,0,0,4) | Details |
| 13676990 | Plesneva SA, Nalivaeva NN, Zhuravin IA: [Adenylate cyclase system of the striatum in rats: regulatory properties and effect of gangliosides]. Ross Fiziol Zh Im I M Sechenova. 1997 Jan-Feb;83(1-2):90-5. |
3(0,0,0,3) | Details |
| 10760099 | Kim SW, Jeon YS, Lee JU, Kang DG, Kook H, Ahn KY, Kim SZ, Cho KW, Kim NH, Han JS, Choi KC: Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats. Kidney Int. 2000 Apr;57(4):1643-50. Immunohistochemical study also showed a markedly decreased expression of AQP2 in the collecting duct in ARF. cAMP generation in response to arginine vasopressin (AVP) in the kidney was attenuated in ARF, most prominently in the outer medulla. cAMP generation in the outer medulla in response to forskolin was not affected, but sodium fluoride was significantly blunted in ARF. |
3(0,0,0,3) | Details |
| 8782082 | Vertongen P, Delhase M, Rajas F, Trouillas J, Hooghe-Peters E, Svoboda M, Robberecht P: Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes are differently expressed in rat transplanted pituitary tumours (SMtTW) and in the normal gland. J Mol Endocrinol. 1996 Jun;16(3):239-48. The expression of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide (PACAP/VIP) receptor subtypes was evaluated in the normal rat pituitary gland and in different rat spontaneous transplantable SMtTW tumours (SMtTW2 which expresses prolactin (PRL), SMtTW10 which expresses GH and SMtTW3 which expresses both PRL and GH) by measurement of PACAP/VIP-stimulated adenylate cyclase activity and detection of the presence of mRNA coding for the different receptor forms. |
3(0,0,0,3) | Details |
| 11124161 | Leon-Velarde F, Bourin MC, Germack R, Mohammadi K, Crozatier B, Richalet JP: Differential alterations in cardiac adrenergic signaling in chronic hypoxia or infusion. Am J Physiol Regul Integr Comp Physiol. 2001 Jan;280(1):R274-81. Stimulated maximal activity of adenylate cyclase decreased in both ventricles with hypoxia (LV, 41%; RV, 36%) but only in LV with NE infusion (42%). |
2(0,0,0,2) | Details |
| 8937929 | Gladziwa U, Klotz U: Adenylate cyclase of gastric mucosa in patients with chronic renal failure. Int J Clin Pharmacol Ther. 1996 Nov;34(11):477-81. |
2(0,0,0,2) | Details |
| 10022774 | Manna PR, Pakarainen P, Rannikko AS, Huhtaniemi IT: Mechanisms of desensitization of follicle-stimulating hormone (FSH) action in a murine granulosa cell line stably transfected with the human FSH receptor complementary deoxyribonucleic acid. Mol Cell Endocrinol. 1998 Nov 25;146(1-2):163-76. Prestimulation of the G-protein activity by sodium fluoride (NaF) or cholera toxin (CT), followed by rhFSH challenge, accounted for a decrease in the cAMP-mediated responsiveness, down to 69.4 +/- 2.8 or 74.2 +/- 1.9%, of control (P < 0.001), respectively, indicating that the post-receptor events are critical for desensitization. [125I] iodo-rhFSH binding to the cells did not change significantly during desensitization and the different stimulations. TPA prestimulation evoked also clear inhibition (65-74% of control) of rhFSH or forskolin (a non-specific activator of adenylate cyclase) induced production. |
1(0,0,0,1) | Details |
| 9639057 | Shibuya J, Ohyanagi M, Nakamura K, Yamamoto J, Iwasaki T: Stimulatory nucleotide-binding protein in failing heart of hamsters and rats. Jpn J Pharmacol. 1998 May;77(1):23-9. The functional activity of Gs was investigated by measuring adenylate cyclase activity. The activity of adenylate cyclase in response to stimulation by sodium fluoride or forskolin was decreased in the BIO 53.58 hamsters relative to control animals, whereas no differences were observed in the ADR rats vs the controls. |
1(0,0,0,1) | Details |
| 12950106 | Baxendale RW, Fraser LR: Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa. Mol Reprod Dev. 2003 Oct;66(2):181-9. In addition to a -regulated soluble adenylyl cyclase (sAC), mammalian spermatozoa, like somatic cells, appear to contain receptor/G protein-regulated AC activity that contributes to the modulation of specialized cell processes. |
1(0,0,0,1) | Details |
| 9410190 | Bolekhan EA, Samoilov MO: [Effect of asphyxia on the adenylate cyclase activity in the cat cerebral cortex] Biull Eksp Biol Med. 1997 Aug;124(8):131-4. |
1(0,0,0,1) | Details |
| 9518573 | Nishigaki N, Chang C, Ichikawa A, Negishi M: Cytoskeletal regulation of the signal transduction of prostaglandin EP4 receptor. Biochim Biophys Acta. 1998 Mar 6;1391(1):110-6. Prostaglandin (PG) EP4 receptor is coupled to Gs, stimulating adenylate cyclase. |
1(0,0,0,1) | Details |
| 12070912 | Shpakov AO, Korol'kov VI, Vlasova EN, Vlasov GP: [Regulation of functional activity of adenylate cyclase signal system by synthetic spiral peptides in cultured fibroblasts of mice strain L (subspecies LSM)] Zh Evol Biokhim Fiziol. 2002 Mar-Apr;38(2):136-41. |
1(0,0,0,1) | Details |
| 10925846 | Shpakov AO, Plesneva SA, Kuznetsova LA: [The role of sulfhydryl groups in activation of the adenylate cyclase signal system by biogenic amines in mollusk and rat tissues] Zh Evol Biokhim Fiziol. 2000 Mar-Apr;36(2):92-6. |
1(0,0,0,1) | Details |
| 8812398 | Bradshaw FJ, Bradshaw SD: Arginine vasotocin: locus of action along the nephron of the ornate dragon lizard, Ctenophorus ornatus. Gen Comp Endocrinol. 1996 Sep;103(3):281-9. The first measurements of AVT-sensitive adenylate cyclase activity in specific segments of the nephron of the Australian arid-zone agamid lizard, Ctenophorus (=Amphibolurus) ornatus, are reported. |
1(0,0,0,1) | Details |
| 10505332 | Shpakov AO, Derkach KV: [The role of sulfhydryl groups in functioning of components of adenylate cyclase signal system in smooth muscles of the mollusk Anodonta cygnea (effect of N-ethylmaleimide and p-chloromercuribenzoic acid)]. Tsitologiia. 1999;41(6):499-505. The alkylating agent N-ethylameimide and the sulfhydryl group blocker p-chloromercuribenzoic acid (CPMA) inhibited in dose-dependent manner both basal activity of adenylyl cyclase (AC) and its activity stimulated by non-hormonal substances (forskolin, sodium fluoride, guanylilimidodiphosphate) in smooth muscles of the freshwater bivalve mollusk Anodonta cygnea. |
1(0,0,0,1) | Details |
| 9502768 | Xiao RP, Tomhave ED, Wang DJ, Ji X, Boluyt MO, Cheng H, Lakatta EG, Koch WJ: Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest. 1998 Mar 15;101(6):1273-82. Thus, we conclude that the positive inotropic effects of both beta1- and beta2-AR stimulation are markedly decreased with aging in rat ventricular myocytes and this is accompanied by decreases in both beta-AR subtype densities and a reduction in membrane adenylate cyclase activity. |
1(0,0,0,1) | Details |
| 12544450 | Girouard H, Chulak C, LeJossec M, Lamontagne D, de Champlain J: Chronic antioxidant treatment improves sympathetic functions and beta-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens. 2003 Jan;21(1):179-88. Plasma concentrations of the isoproterenol-induced relaxation in mesenteric arteries, the total density and affinity of beta-adrenoceptors in the heart, and the adenylate cyclase reactivity of cardiac membranes to isoproterenol, forskolin, sodium fluoride and guanylylimidophosphate were not altered by the treatments. |
0(0,0,0,0) | Details |
| 17898545 | Ross GR, Yallampalli U, Yallampalli C: Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery. J Vasc Res. 2008;45(1):33-44. Epub 2007 Sep 26. Interestingly, sodium fluoride, a nonspecific protein phosphatase inhibitor, completely blocked the effect of adrenomedullin on CaCl (2)-induced contraction. |
0(0,0,0,0) | Details |