Protein Information

Name enolase
Synonyms 2 phospho D glycerate hydrolyase; T suppressor LYMPHOKINE; 2 phospho D glycerate hydro lyase; Enolase; Beta enolase; ENO 3; ENO3; Enolase 3…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
19060940 Kosenko EA, Solomadin IN, Marov NV, Venediktova NI, Pogosian AS, Kaminskii IuG: [Role of glycolysis and antioxidant enzymes in the toxicity of amyloid beta peptide Abeta25-35 to erythrocytes]. Bioorg Khim. 2008 Sep-Oct;34(5):654-60.

The erythrotoxicity of Abeta (25-35) was shown to increase two- to fourfold both in the absence of glucose in the incubation medium and upon the addition of sodium fluoride, an enolase inhibitor.
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18832829 van Loveren C, Hoogenkamp MA, Deng DM, ten Cate JM: Effects of different kinds of fluorides on enolase and ATPase activity of a fluoride-sensitive and fluoride-resistant Streptococcus mutans strain. Caries Res. 2008;42(6):429-34. Epub 2008 Oct 3.

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9217309 Kerai MD, Timbrell JA: Effect of fructose on the biochemical toxicity of hydrazine in isolated rat hepatocytes. Toxicology. 1997 Jul 11;120(3):221-30.

This study also demonstrated that fluoride, an enolase inhibitor, abolished the protection against depletion of ATP levels provided by fructose, without affecting cell viability or GSH levels.
In certain experiments in which fructose was added, the glycolytic inhibitor sodium fluoride (3 mM) was also added during the preincubation period.
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8660580 Silveira MC, Carvajal E, Bon EP: Assay for in vivo yeast invertase activity using NaF. Anal Biochem. 1996 Jun 15;238(1):26-8.

In this method the cells were preincubated with 50 mM sodium fluoride, and inhibitor of enolase.
In this method the cells were preincubated with 50 mM sodium fluoride, and inhibitor of enolase.
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11110164 Nishikimi A, Uekawa N, Yamada M: Involvement of glycolytic metabolism in developmental inhibition of rat two-cell embryos by phosphate. J Exp Zool. 2000 Dec 1;287(7):503-9.


Addition of an inhibitor of enolase in glycolysis, sodium fluoride (NaF), at 1 mM to the Glc (-) medium also enhanced the inhibitory effects of 10 microM phosphate, whereas 1 mM NaF in the absence of phosphate showed no inhibitory effects on the development of 2-cell embryos to morula and blastocyst stages.
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