Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
12116726 Lang NP, Sander L, Barlow A, Brennan K, White DJ, Bacca L, Bartizek RD, McClanahan SF: Experimental gingivitis studies: effects of triclosan and triclosan-containing dentifrices on dental plaque and gingivitis in three-week randomized controlled clinical trials. J Clin Dent. 2002;13(4):158-66.


In study 1, test articles were dentifrice products (0.28% triclosan/5% pyrophosphate/0.145% sodium fluoride, 0.2% triclosan/0.5% zinc citrate/0.112% sodium fluoride, 0.145% sodium fluoride and 0.15% sodium monofluorophosphate) applied neat and undiluted via a performed tooth shield (that prevents mechanical tooth-brushing at the test sites in the oral cavity) in a partial mouth design.
0(0,0,0,0) Details
17028382 Birkner E, Grucka-Mamczar E, Zalejska-Fiolka J, Chlubek D, Kasperczyk S, Stawiarska-Pieta B, Blaszczyk U: Influence of sodium fluoride and caffeine on the concentration of fluoride ions, glucose, and urea in blood serum and activity of protein metabolism enzymes in rat liver. Biol Trace Elem Res. 2006 Aug;112(2):169-74.

Also determined were the activities of aspartate aminotransferase, alanine aminotransferase glutamate dehydrogenase, ornithine carbamoylotransferase and arginase in liver homogenates.
1(0,0,0,1) Details
19425189 Kanbur M, Eraslan G, Silici S, Karabacak M: Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. Food Chem Toxicol. 2009 Jun;47(6):1184-9.

Furthermore, serum cholesterol, triglyceride, glucose, total protein and albumin levels, and aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alcaline phosphatase (ALP) activities were evaluated.
1(0,0,0,1) Details
14601470 Mazurek-Mochol M: [Interaction between fluorine and zinc after long-term oral administration into the digestive system of rats]. Ann Acad Med Stetin. 2002;48:75-83.

The aim of this study was to search for interactions in rats between fluoride and zinc administered orally for 12 weeks and to elucidate any potential toxicological and therapeutic consequences. 60 male Wistar rats were divided into six groups of ten rats each and exposed to: 1. controls (distilled water); 2. sodium fluoride (NaF); 3. low-dose zinc (Zn); 4. high-dose zinc; 5.
Serum alkaline phosphatase, alanine and aspartate aminotransferase activities, as well as bilirubin and creatinine concentrations were determined to confirm non-toxicity of fluoride dose.
1(0,0,0,1) Details
17581686 Miranda LC, Viaro F, Ceneviva R, Evora PR: Endothelium-dependent and -independent hepatic artery vasodilatation is not impaired in a canine model of liver ischemia-reperfusion injury. Braz J Med Biol Res. 2007 Jun;40(6):857-65.

The nitric oxide endothelium-dependent relaxation of hepatic artery rings contracted with prostaglandin F2a and exposed to increasing concentrations of acetylcholine, calcium ionophore A23187, sodium fluoride, phospholipase-C, poly-L-arginine, isoproterenol, and sodium nitroprusside was evaluated in organ-chamber experiments.
Lipid peroxidation was estimated by malondialdehyde activity in liver tissue samples and by blood lactic dehydrogenase (LDH), serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) activities.
1(0,0,0,1) Details
18506400 Birkner E, Grucka-Mamczar E, Kasperczyk S, Kasperczyk A, Stawiarska-Pieta B, Zalejska-Fiolka J, Birkner B: The influence of fluoride ions upon selected enzymes of protein metabolism in blood plasma of rabbits with hypercholesterolemia. Biol Trace Elem Res. 2008 Aug;124(2):118-28. Epub 2008 May 28.

The influence of fluoride ions has been examined upon the activity of alanine aminotransferase, aspartate aminotransferase, and glutamate dehydrogenase (GLDH) in the plasma in the liver of rabbits in the course of experimental hypercholesterolemia.
The addition of sodium fluoride to the diet rich in cholesterol results in "removing the block" on those activities, which increase.
1(0,0,0,1) Details
10909490 Bialecki P: [Evaluation of the repair process in mechanically injured rat bone stimulated by sodium fluoride with non-toxic doses]. Ann Acad Med Stetin. 1999;45:195-209.

The following parameters were evaluated in blood serum: fluorine, calcium, magnesium contents, serum concentrations of urea, creatinine, bilirubin and activity levels of enzymes: aspartate aminotransferase, alanine aminotransferase, cholinesterase, base phosphatase.
1(0,0,0,1) Details
8880818 Komatsu H, Ueki M, Morita J, Chujo K, Ogli K: Clinical characteristics and biotransformation of sevoflurane in paediatric patients during antiepileptic drug therapy. Paediatr Anaesth. 1996;6(5):379-82.

Plasma F- analysis was performed at the stages of: 1) induction of anaesthesia, 2) conclusion of anaesthesia, 3) 15 h after the conclusion of anaesthesia, using an ion-selective electrode calibrated with a standard solution of sodium fluoride.
Pre- and postoperative hepatic (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin) and renal (blood urea nitrogen, creatinine) function was tested.
1(0,0,0,1) Details
19709569 Kanbur M, Eraslan G, Silici S, Karabacak M: Effects of Sodium Fluoride Exposure on Some Biochemical Parameters in Mice: Evaluation of The Ameliorative Effect of Royal Jelly Applications on These Parameters. Food Chem Toxicol. 2009 Feb 10.

Furthermore, serum cholesterol, triglyceride, glucose, total protein and albumin levels, and aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alcaline phosphatase (ALP) activities were evaluated.
1(0,0,0,1) Details
16892582 Grucka-Mamczar E, Birkner E, Stawiarska-Pieta B, Duliban H, Polaniak R, Chlubek D, Samujlo D, Ceglowska A: [Activities of some enzymes and concentration of ammonia in serum of rats with fluoride hyperglycemia]. Ann Acad Med Stetin. 2004;50 Suppl 1:36-41.

Hyperglycemia was induced with sodium fluoride in water at a concentration of 50 or 100 mg/L during four months.
We observed significantly (p < 0.05) reduced activities of aspartate aminotransferase (by 22.8%) and malic dehydrogenase (by 10.9%) in the group exposed to 100 mg F (-)/L.
1(0,0,0,1) Details