Protein Information

Name IL 8
Synonyms 3 10C; AMCF I; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP 1; GCP1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
11567778 Refsnes M, Thrane EV, Lag M, Thoresen GH, Schwarze PE: Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells. Toxicology. 2001 Oct 15;167(2):145-58.

Sodium fluoride (NaF) has previously been reported to induce a strong IL-8 response in human epithelial lung cells (A549) via mechanisms that seem to involve the activation of G proteins.
38(0,1,1,8) Details
17996917 Refsnes M, Skuland T, Schwarze PE, Ovrevik J, Lag M: Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation. Toxicol Appl Pharmacol. 2008 Feb 15;227(1):56-67. Epub 2007 Oct 3.

Sodium fluoride strongly activated MAPK, in particular JNK1/2 and p38.
8(0,0,0,8) Details
10594545 Arnold R, Rihoux J, Konig W: Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549). Clin Exp Allergy. 1999 Dec;29(12):1681-91.

8(0,0,0,8) Details
10602388 Refsnes M, Becher R, Lag M, Skuland T, Schwarze PE: Fluoride-induced interleukin-6 and interleukin-8 synthesis in human epithelial lung cells. Hum Exp Toxicol. 1999 Nov;18(11):645-52.

In the present study the potential of sodium fluoride (NaF) and HF to induce cytokine response was examined and how these responses are modulated by Al3+ in a human epithelial lung cell line (A549).
5(0,0,0,5) Details
12472997 Mostefaoui Y, Claveau I, Ross G, Rouabhia M: Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices. J Clin Periodontol. 2002 Nov;29(11):1035-41.

3(0,0,0,3) Details
8926049 Hilger RA, Koller M, Konig W: Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502. Inflammation. 1996 Feb;20(1):57-70.

After incubation of the cell population with different concentrations of SM-12502 the cells were subsequently stimulated with either the Ca ionophore A23187, the bacterial derived peptide fMLP, or with an activator of heterotrimetric G-proteins, the sodium fluoride (NaF, in the presence of Al3+).
3(0,0,0,3) Details
8555272 Richard A, Bourgoin S, Naccache PH, L'Heureux GP, Krump E, McColl SR, Pelletier G: C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils. Biochim Biophys Acta. 1996 Jan 19;1299(2):259-66.


C2-ceramide at 2 microM did not enhance the production of O2- induced by 100 nM recombinant human interleukin-8 (IL-8), leukotriene B4 (LTB4), platelet-activating factor (PAF) or 20 mM sodium fluoride (NaF).
0(0,0,0,0) Details