Protein Information

Name caspase 9
Synonyms APAF 3; APAF3; Apoptotic protease MCH6; Apoptotic protease Mch 6; Apoptotic protease activating factor 3; CASP 9; CASP9; CASPASE 9c…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
19009284 Yan X, Feng C, Chen Q, Li W, Wang H, Lv L, Smith GW, Wang J: Effects of sodium fluoride treatment in vitro on cell proliferation, apoptosis and caspase-3 and caspase-9 mRNA expression by neonatal rat osteoblasts. Arch Toxicol. 2009 May;83(5):451-8. Epub 2008 Oct 21.
13(0,0,2,3) Details
16136339 Zhan XA, Wang M, Xu ZR, Li WF, Li JX: Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs. Arch Toxicol. 2006 Feb;80(2):74-80. Epub 2005 Sep 1.


The obvious DNA ladder and the significantly increased both hepatic caspase-9 and caspase-3 activity indicated that fluoride induced caspase-dependent apoptosis in vivo.
2(0,0,0,2) Details
14981920 Morshed SR, Tokunaga T, Otsuki S, Takayama F, Satoh T, Hashimoto K, Yasui T, Okamura M, Shimada J, Kashimata M, Sakagami H: Effect of antitumor agents on cytotoxicity induction by sodium fluoride. . Anticancer Res. 2003 Nov-Dec;23(6C):4729-36.

Caspase 8 (involved in non-mitochondrial extrinsic pathway) and caspase 9 (involved in mitochondrial intrinsic pathway) were also activated, but to a much lesser extent.
1(0,0,0,1) Details
19322641 Agarwal R, Mumtaz H, Ali N: Role of inositol polyphosphates in programmed cell death. Mol Cell Biochem. 2009 Aug;328(1-2):155-65. Epub 2009 Mar 26.


Additionally, we measured changes in AKT phosphorylation, cleavage of caspase-3 and caspase-9, and release of cytochrome C from mitochondria into cytosol.
1(0,0,0,1) Details
18069112 Lee JH, Jung JY, Jeong YJ, Park JH, Yang KH, Choi NK, Kim SH, Kim WJ: Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts. Toxicology. 2008 Jan 20;243(3):340-7. Epub 2007 Nov 4.

In addition, NaF increased the level of cytochrome c released from the mitochondria into the cytosol, enhanced the caspase-9, -8 and -3 activities, the cleavage of poly (ADP-ribose) polymerase (PARP), and up-regulated the voltage-dependent anion channel (VDAC) 1.
1(0,0,0,1) Details
16309196 Takeuchi R, Hoshijima H, Onuki N, Nagasaka H, Chowdhury SA, Kawase M, Sakagami H: Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. Anticancer Res. 2005 Nov-Dec;25(6B):4037-41.


The cytotoxic activity of codeinone against HSC-2 cells was inhibited by N-acetyl-L-cysteine, but somewhat additively stimulated by sodium ascorbate, epigallocatechin gallate, hydrogen peroxide, sodium fluoride, 5-fluorouridine, cisplatin, doxorubicin and methotrexate.
0(0,0,0,0) Details