Protein Information

Name ATPases
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
12071426 Ekambaram P, Paul V: Modulation of fluoride toxicity in rats by calcium carbonate and by withdrawal of fluoride exposure. Pharmacol Toxicol. 2002 Feb;90(2):53-8.

In order to assess the effect of calcium on the toxic effects of fluoride, adult female Wistar rats were treated with sodium fluoride (NaF, 500 ppm in drinking water) alone or in combination with calcium carbonate (CaCO3, 50 mg/ kg by oral intubation) daily for 60 days.
Body weight gain, exploratory motor activity, rota-rod motor coordination, dental structure, activities of acetylcholinesterase (AchE, brain and skeletal muscle) and Na+ K+ ATPase (erythrocyte membrane and skeletal muscle) and the concentrations of protein (serum and skeletal muscle), calcium (serum) and fluoride (serum) were determined in these animals 24 hr after the last treatment.
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9888269 Yaktubay N, Ogulener N, Onder S, Baysal F: Possible stimulation of Na+-K+-ATPase by NO produced from sodium nitrite by ultraviolet light in mouse gastric fundal strip. Gen Pharmacol. 1999 Jan;32(1):159-62.

In the present study, we investigated the roles of Na+-K+-ATPase and extracellular Na+ or Ca2+ ions in ultraviolet (UV) light-induced photorelaxation of methacholine-contracted mouse isolated gastric fundus in the presence of NaNO2 (50 microM). 2.
Metabolic inhibitors, sodium azide (10-100 microM), 2,4-dinitrophenol (100 microM to 1 mM) and sodium fluoride (100 microM to 1 mM) significantly reduced photorelaxation. 4.
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9570787 Rose CR, Waxman SG, Ransom BR: Effects of glucose deprivation, chemical hypoxia, and simulated ischemia on Na+ homeostasis in rat spinal cord astrocytes. J Neurosci. 1998 May 15;18(10):3554-62.


Combined glycolytic and respiratory blockage by NaN3 and 0 glucose saline caused [Na+] i to increase by 20 mM, similar to the [Na+] i increases elicited by blocking the Na+/K+-ATPase with ouabain.
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12638610 Popova AF: The ultrastructure of Chlorella mitochondria and their energetic state under altered gravity. J Gravit Physiol. 2001 Jul;8(1):P27-8.


The localization of the Mg (2+)-activated ATPases were studied during the culture development under the geterotrophic conditions, and with an investigation of the mitochndria ultrastructure at the various stages of the culture development under clinorotation.
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9371849 Hansson M, Kannangara CG: ATPases and phosphate exchange activities in magnesium chelatase subunits of Rhodobacter sphaeroides. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13351-6.

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11081793 Phan TN, Reidmiller JS, Marquis RE: Sensitization of Actinomyces naeslundii and Streptococcus sanguis in biofilms and suspensions to acid damage by fluoride and other weak acids. Arch Microbiol. 2000 Oct;174(4):248-55.


Thus, the weak acids thwarted the functions of F (H+)-ATPases in extruding protons and protecting cells against acid damage.
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14629005 Alves-Ferreira M, Dutra PM, Lopes AH, Ferreira-Pereira A, Scofano HM, Meyer-Fernandes JR: Magnesium-dependent ecto-ATP diphosphohydrolase activity in Herpetomonas muscarum muscarum. Curr Microbiol. 2003 Oct;47(4):265-71.

Classical inhibitors of acid phosphatases, such as sodium orthovanadate (NaVO3), sodium fluoride (NaF), and ammonium molybdate presented no effect on this activity.
The ecto-ATPase activity was insensitive to oligomycin and sodium azide, two inhibitors of mitochondrial Mg-ATPase, bafilomycin A1, a V-ATPase inhibitor, ouabain, a Na (+)+K+-ATPase inhibitor and to levamizole, an inhibitor of alkaline phosphatase.
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19955819 Ma SK, Bae EH, Kim IJ, Choi C, Lee J, Kim SW: Altered renal expression of aquaporin water channels and sodium transporters in rats with two-kidney, one-clip hypertension. Kidney Blood Press Res. 2009;32(6):411-20. Epub 2009 Dec 3.

The adenylyl cyclase activity provoked by arginine vasopressin, sodium fluoride or forskolin was blunted in the clipped kidney, but remained unaltered in the contralateral kidney.
The expressions of the Na,K-ATPase alpha1-subunit, type 3 Na (+)/H (+) exchanger, Na-K-2Cl cotransporter and epithelial sodium channels were decreased in the clipped kidney, while remaining unchanged in the non-clipped kidney.
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9016786 Chen HK, Yeh NH: The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. Biochem Biophys Res Commun. 1997 Jan 13;230(2):370-5.


It is known that F- and Mg2+ act on many GTPases and ATPases through the induction of a conformational transition mimicking the nucleoside triphosphate-bound state.
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