Protein Information

Name protein phosphatase 2A (protein family or complex)
Synonyms PP2A; PPP2; PPP2A; protein phosphatase 2; protein phosphatase 2A

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
11494123 Jaumot M, Hancock JF: Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene. 2001 Jul 5;20(30):3949-58.

General serine-threonine phosphatase inhibitors such sodium fluoride, or ss-glycerophosphate and sodium pyrophosphate, or specific PP1 and PP2A inhibitors including microcystin-LR, protein phosphatase 2A inhibitor I (1) or protein phosphatase inhibitor 2 all abrogate H-Ras and K-Ras dependent Raf-1 activation in vitro.
31(0,1,1,1) Details
16407301 Fritz A, Brayer KJ, McCormick N, Adams DG, Wadzinski BE, Vaillancourt RR: Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation. J Biol Chem. 2006 Mar 10;281(10):6236-45. Epub 2006 Jan 9.

In addition, phosphorylation of Ser526 was required for MKK6 phosphorylation in vitro, whereas dephosphorylation of Ser526 was mediated by protein phosphatase 2A and sensitive to okadaic acid and sodium fluoride.
31(0,1,1,1) Details
15075332 Hashigasako A, Machide M, Nakamura T, Matsumoto K, Nakamura T: Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor. J Biol Chem. 2004 Jun 18;279(25):26445-52. Epub 2004 Apr 9.

2(0,0,0,2) Details
10467181 Nishito Y, Usui H, Tanabe O, Shimizu M, Takeda M: Interconversion of Mn (2+)-dependent and -independent protein phosphatase 2A from human erythrocytes: role of Zn (2+) and Fe (2+) in protein phosphatase 2A. J Biochem. 1999 Sep;126(3):632-8.

1(0,0,0,1) Details
12154141 Rivoal J, Turpin DH, Plaxton WC: In vitro phosphorylation of phosphoenolpyruvate carboxylase from the green alga Selenastrum minutum. Plant Cell Physiol. 2002 Jul;43(7):785-92.


Treatment of purified PEPC2 with protein phosphatase 2A (2) increased its apparent M (r) as judged by Superose 6 gel filtration chromatography.
1(0,0,0,1) Details