Protein Information

Name phospholipase D (protein family or complex)
Synonyms Phospholipase D

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
8915773 Bourgoin SG, Harbour D, Poubelle PE: Role of protein kinase C alpha, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells. J Bone Miner Res. 1996 Nov;11(11):1655-65.
82(1,1,1,2) Details
8764605 Kanfer JN, McCartney D, Singh IN, Freysz L: Phospholipase D activity of rat brain neuronal nuclei. . J Neurochem. 1996 Aug;67(2):760-6.

7(0,0,0,7) Details
8931111 Kozawa O, Suzuki A, Shinoda J, Oiso Y: Effect of retinoic acid on prostaglandin F2 alpha-induced phospholipase D activity in osteoblast-like cells. Prostaglandins Leukot Essent Fatty Acids. 1996 Sep;55(3):151-4.

4(0,0,0,4) Details
9581864 Tokuda H, Kozawa O, Harada A, Uematsu T: Tiludronate inhibits interleukin-6 synthesis in osteoblasts: inhibition of phospholipase D activation in MC3T3-E1 cells. J Cell Biochem. 1998 Jun 1;69(3):252-9.

3(0,0,0,3) Details
11968002 Hatakeyama D, Kozawa O, Otsuka T, Shibata T, Uematsu T: Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D. J Cell Biochem. 2002;85(3):621-8.

3(0,0,0,3) Details
8954949 Cao YZ, Reddy PV, Sordillo LM, Hildenbrandt GR, Reddy CC: Evidence for G-protein-dependent and G-protein-independent activation of phospholipase D in lymphocytes. Biochem Biophys Res Commun. 1996 Dec 13;229(2):630-4.

2(0,0,0,2) Details
9882708 Ushio-Fukai M, Alexander RW, Akers M, Lyons PR, Lassegue B, Griendling KK: Angiotensin II receptor coupling to phospholipase D is mediated by the betagamma subunits of heterotrimeric G proteins in vascular smooth muscle cells. Mol Pharmacol. 1999 Jan;55(1):142-9.

In intact cells, Ang II activation of PLD was pertussis toxin-insensitive and was not additive with sodium fluoride, a cell-permeant activator of heterotrimeric G proteins, indicating that AT1 receptor-PLD coupling requires pertussis toxin-insensitive heterotrimeric G proteins.
2(0,0,0,2) Details
8647917 Suzuki A, Kozawa O, Shinoda J, Watanabe Y, Saito H, Oiso Y: Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis. J Cell Physiol. 1996 Jul;168(1):209-16.


We examined the effect of thrombin on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.
2(0,0,0,2) Details
9075338 Kovacs P, Csaba G, Nakashima S, Nozawa Y: Phospholipase D activity in the Tetrahymena pyriformis GL. Cell Biochem Funct. 1997 Mar;15(1):53-60.

In Tetrahymena pyriformis GL this enzyme activity is enhanced by different kinds of agonists (sodium orthovanadate, sodium fluoride and phorbol 12-myristate 13-acetate), and its activity can be inhibited by inhibitors such as pertussis toxin, calphostin C, genistein, trifluoperazine.
2(0,0,0,2) Details
8938585 Capito K, Hansen SE, Thams P: Production of [3H] choline-labelled metabolites from endogenously 3H-labelled phosphatidylcholine in mouse pancreatic islets. J Mol Endocrinol. 1996 Oct;17(2):101-7.


Phospholipase C (PLC) and phospholipase D (PLD) activities were demonstrated and also that of an enzyme that removes both fatty acids from PC and thus catalyses the production of [3H] glycerophosphorylcholine (GroPCho).
1(0,0,0,1) Details