| Name | caspase (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14666669 | Tokunaga T, Morshed SR, Otsuki S, Takayama F, Satoh T, Hashimoto K, Yasui T, Ogawa S, Kanegae H, Yokote Y, Akahane K, Kashimata M, Satoh K, Sakagami H: Effect of antioxidants, oxidants, metals and saliva on cytotoxicity induction by sodium fluoride. Anticancer Res. 2003 Sep-Oct;23(5A):3719-26. We have recently found that millimolar concentrations of sodium fluoride (NaF) induced apoptotic cell death, characterized by caspase activation and DNA fragmentation, in tumor cell lines. |
31(0,1,1,1) | Details |
| 19852076 | Xu B, Xu Z, Xia T, He P, Gao P, He W, Zhang M, Guo L, Niu Q, Wang A: Effects of the Fas/Fas-L pathway on -induced apoptosis in SH-SY5Y cells. Environ Toxicol. 2009 Oct 22. To investigate apoptosis, caspase-3 activity, and mRNA expression of Fas, Fas-L, and caspases (-3 and -8) induced by human neuroblastoma (SH-SY5Y) cells were incubated with 0, 20, 40, and 80 mg/L sodium fluoride (NaF) for 24 h in vitro. |
7(0,0,1,2) | Details |
| 16183791 | Otsuki S, Morshed SR, Chowdhury SA, Takayama F, Satoh T, Hashimoto K, Sugiyama K, Amano O, Yasui T, Yokote Y, Akahane K, Sakagami H: Possible link between glycolysis and apoptosis induced by sodium fluoride. . J Dent Res. 2005 Oct;84(10):919-23. NaF-induced apoptotic cell death is characterized by caspase activation, internucleosomal DNA fragmentation, loss of mitochondrial membrane potential, and production of apoptotic bodies. |
2(0,0,0,2) | Details |
| 16136339 | Zhan XA, Wang M, Xu ZR, Li WF, Li JX: Evaluation of caspase-dependent apoptosis during -induced liver lesion in pigs. Arch Toxicol. 2006 Feb;80(2):74-80. Epub 2005 Sep 1. |
2(0,0,0,2) | Details |
| 15849362 | Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML, Nguyen L, Urano F, Bartlett JD: induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem. 2005 Jun 17;280(24):23194-202. Epub 2005 Apr 23. LS8 cells were growth-inhibited by as little as 1.9-3.8 ppm whereas higher doses induced ER stress and caspase-mediated DNA fragmentation. |
1(0,0,0,1) | Details |
| 17447005 | Isakovic A, Harhaji L, Stevanovic D, Markovic Z, Sumarac-Dumanovic M, Starcevic V, Micic D, Trajkovic V: Dual antiglioma action of cell cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci. 2007 May;64(10):1290-302. In confluent C6 cultures, on the other hand, caused massive induction of caspase-dependent apoptosis associated with c-Jun N-terminal kinase (JNK) activation, mitochondrial depolarization and oxidative stress. -triggered apoptosis was completely prevented by agents that block mitochondrial permeability transition (cyclosporin A) and radical production (N-acetylcisteine), while the inhibitors of JNK activation (SP600125) or glycolysis (sodium fluoride, iodoacetate) provided partial protection. |
1(0,0,0,1) | Details |
| 19414411 | Chien CH, Sakagami H, Kouhara M, Sasaki A, Matsumoto K, Kanegae H: Effect of simulated orthodontic forces on -induced cytotoxicity in MC3T3-E1 osteoblast-like cells. In Vivo. 2009 Mar-Apr;23(2):259-65. The effects of simulated orthodontic forces such as centrifugal force or water pressure on sodium fluoride (NaF)-induced cytotoxicity against mouse osteoblast-like cells MC3T3-E1 were investigated. The present study demonstrates that centrifugal force and water pressure partially enhanced the caspase-independent cytotoxicity of NaF against osteoblasts. |
1(0,0,0,1) | Details |
| 16161253 | Satoh R, Kishino K, Morshed SR, Takayama F, Otsuki S, Suzuki F, Hashimoto K, Kikuchi H, Nishikawa H, Yasui T, Sakagami H: Changes in sensitivity during in vitro senescence of normal human oral cells. Anticancer Res. 2005 May-Jun;25(3B):2085-90. We have previously reported that sodium fluoride (NaF) showed slightly higher cytotoxicity against human oral tumor cell lines than normal human oral cells. NaF produced large DNA fragments, without induction of internucleosomal DNA fragmentation, possibly due to weak activation of caspases -3, -8 and -9. |
1(0,0,0,1) | Details |
| 14758725 | Tokunaga T, Morshed SR, Otsuki S, Takayama F, Hashimoto K, Kashimata M, Nakamura Y, Nishikawa H, Yasui T, Yokote Y, Akahane K, Sakagami H: Effect of endodontic agents on cytotoxicity induction by sodium fluoride. . In Vivo. 2003 Nov-Dec;17(6):583-91. |
0(0,0,0,0) | Details |