Protein Information

Name Atrial natriuretic peptide
Synonyms ANF; ANP; Atrial natriuretic factor; Atrial natriuretic factor precursor; Atrial natriuretic peptide; Atrial natriuretic polypeptide; Atrionatriureticfactor; Atriopeptin…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
7907323 Haxhiu MA, Deal EC, Van Lunteren E, Cherniack NS: Central effects of somatostatin and atrial natriuretic peptide on tracheal tone. J Appl Physiol. 1993 Dec;75(6):2353-9.

The effects of somatostatin and atrial natriuretic peptide applied topically to the ventral surface of the medulla (VMS) on tracheal tone and phrenic nerve activity (Phr) were studied in chloralose-anesthetized and paralyzed cats artificially ventilated with 7% CO2 in O2.
10(0,0,1,5) Details
8845142 Drake-Holland AJ, Song G, Belcher PR, Noble MI: Natriuresis caused by blood volume expansion in dogs is not mediated by the renal nerves. Exp Physiol. 1996 Mar;81(2):285-95.

The influence of renal denervation on the renal response to rapid blood volume expansion was investigated by measurement of urine volume, sodium and osmolar excretion rates, sodium p-aminohippurate and free water clearances, and systemic haemodynamic and plasma hormone (atrial natriuretic peptide, arginine vasopressin and plasma renin activity (PRA)) changes in ten control and ten renal-denervated chloralose-anaesthetized mongrel dogs.
6(0,0,1,1) Details
8567055 Zhu ST, Chen YF, Wyss JM, Nakao K, Imura H, Oparil S, Calhoun DA: Atrial natriuretic peptide blunts arterial baroreflex in spontaneously hypertensive rats. Hypertension. 1996 Feb;27(2):297-302.

After urethane- and alpha-chloralose-induced induced anesthesia, arterial baroreflex-mediated control of heart rate and lumbar sympathetic nerve activity was assessed during phenylephrine- (5 to 40 micrograms.kg-1.min-1) induced increases and sodium nitroprusside- (15 to 300 micrograms.kg-1.min-1) induced decreases in mean blood pressure before and after microinjection of ANP (50 ng) or monoclonal antibody to ANP (0.55 micrograms) into the caudal nucleus tractus solitarii.
2(0,0,0,2) Details
16403067 Stambler BS, Guo GB: Atrial natriuretic peptide has dose-dependent, autonomically mediated effects on atrial refractoriness and repolarization in anesthetized dogs. J Cardiovasc Electrophysiol. 2005 Dec;16(12):1341-7.

METHODS AND RESULTS: Electrophysiologic and hemodynamic effects of ANP infusion (human ANP at 15-600 ng/kg per minute) were examined in chloralose-anesthetized dogs under conditions of varying autonomic blockade.
2(0,0,0,2) Details
1840408 al-Obaidi M, Whitaker EM, Karim F: The effect of discrete stimulation of carotid body chemoreceptors on atrial natriuretic peptide in anaesthetized dogs. J Physiol. 1991 Nov;443:519-31.

In seven chloralose-anaesthetized and artificially ventilated beagles, the carotid sinus regions were vascularly isolated and perfused with either arterial or mixed (arterial and venous) blood (PO2 46.4 +/- 1.5 mmHg, mean +/- S.E.M.) to stimulate the chemoreceptors at constant flow and pressure.
2(0,0,0,2) Details
11101194 Rastegar MA, Vegh A, Papp JG, Parratt JR: Atrial natriuretic peptide reduces the severe consequences of coronary artery occlusion in anaesthetized dogs. Cardiovasc Drugs Ther. 2000 Oct;14(5):471-9.

In chloralose-urethane anaesthetised mongrel dogs either saline (controls) or human synthetic ANP was infused intravenously (10 microg kg (-1) + 0.1 microg kg (-1) min (-1)), starting 30 min before and continuing 10 min during a 25 min occlusion of the left anterior descending coronary artery (LAD).
2(0,0,0,2) Details
7722147 Evans MA, Burnett JC Jr, Redfield MM: Effect of low dose aspirin on cardiorenal function and acute hemodynamic response to enalaprilat in a canine model of severe heart failure. J Am Coll Cardiol. 1995 May;25(6):1445-50.

Cardiorenal and neurohumoral function was measured during chloralose anesthesia.
RESULTS: Both groups demonstrated severe heart failure with decreased cardiac output; increased atrial pressures and systemic resistance; activation of plasma renin activity, aldosterone and atrial natriuretic factor; and sodium retention.
1(0,0,0,1) Details