Protein Information

Name p42
Synonyms CDC2 related kinase 1; p42; CDKL 1; CDKL1; Cyclin dependent kinase like 1; KKIALRE; Protein kinase p42 KKIALRE; Serine/threonine protein kinase KKIALRE…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
11029753 Kozawa O, Yamamoto T, Tanabe K, Akamatsu S, Dohi S, Uematsu T: Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. J Cell Biochem. 2000 Sep 18;80(1):46-52.


We previously reported that sphingosine 1-phosphate (S-1-P), a sphingomyelin metabolite, activates p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in aortic smooth-muscle A10 cells.
2(0,0,0,2) Details
11968002 Hatakeyama D, Kozawa O, Otsuka T, Shibata T, Uematsu T: Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D. J Cell Biochem. 2002;85(3):621-8.


We previously reported that prostaglandin F2alpha (PGF2alpha) induces phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein, resulting in the activation of protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells and that PGF2alpha stimulates the synthesis of interleukin-6 (IL-6) via PKC-dependent p44/p42 mitogen-activated protein (MAP) kinase activation.
2(0,0,0,2) Details
10376804 Tokuda H, Kozawa O, Harada A, Uematsu T: p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts. Cell Signal. 1999 May;11(5):325-30.

6(0,0,0,6) Details
12646577 Tokuda H, Harada A, Hirade K, Matsuno H, Ito H, Kato K, Oiso Y, Kozawa O: Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. J Biol Chem. 2003 May 23;278(21):18930-7. Epub 2003 Mar 19.


We have previously reported that prostaglandin F2 alpha (PGF2 alpha) activates p44/p42 mitogen-activated protein kinase (MAPK) through protein kinase C (PKC) in osteoblast-like MC3T3-E1 cells.
1(0,0,0,1) Details