Protein Information

Name casein
Synonyms Alpha; Alpha s1 casein; Alpha s1 casein precursor; CASA; CSN 1; CSN1; CSN1S1; Casein…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
17977295 Andersson A, Skold-Larsson K, Hallgren A, Petersson LG, Twetman S: Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence. Oral Health Prev Dent. 2007;5(3):229-33.

PURPOSE: To investigate and compare the effects of a dental cream containing complexes of casein phosphoprotein-amorphous calcium phosphate (CPP-ACP) and fluoride mouthwashes on the regression of white spot lesions (WSL).
The patients were randomly assigned to two different treatment protocols with the aim of remineralising the lesions: A) daily topical applications of a dental cream containing CPP-ACP (Topacal) for 3 months followed by a 3-month period of daily toothbrushing with fluoridated dentifrice, or B) daily 0.05% sodium fluoride mouthwash combined with fluoridated dentifrice for 6 months.
1(0,0,0,1) Details
12466482 Hui EK, Nayak DP: Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells. J Gen Virol. 2002 Dec;83(Pt 12):3055-66.

In this report, we demonstrate that G protein signalling stimulators such as sodium fluoride, aluminium fluoride, compound 48/80 and mastoparan stimulated the budding and release of influenza virus.
However, the casein kinase 2 (CK2) inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole decreased virus budding.
1(0,0,0,1) Details
19887683 Bailey DL, Adams GG, Tsao CE, Hyslop A, Escobar K, Manton DJ, Reynolds EC, Morgan MV: Regression of post-orthodontic lesions by a remineralizing cream. J Dent Res. 2009 Dec;88(12):1148-53. Epub 2009 Nov 3.


A clinical trial was conducted to test whether, in a post-orthodontic population using fluoride toothpastes and receiving supervised fluoride mouthrinses, more lesions would regress in participants using a remineralizing cream containing casein phosphopeptide- amorphous calcium phosphate compared with a placebo.
1(0,0,0,1) Details
11925535 Hay KD, Thomson WM: A clinical trial of the anticaries efficacy of casein derivatives complexed with calcium phosphate in patients with salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar;93(3):271-5.

OBJECTIVE: The purpose of this study was to compare the caries preventive efficacy of a mouthrinse solution containing casein derivatives coupled with calcium phosphate (CD-CP) with that of a 0.05% sodium fluoride mouthrinse among individuals with dry mouth.
32(0,1,1,2) Details
12271345 Holler BE, Friedl KH, Jung H, Hiller KA, Schmalz G: Fluoride uptake and distribution in enamel and dentin after application of different fluoride solutions. Clin Oral Investig. 2002 Sep;6(3):137-44. Epub 2002 Jul 25.

The buccal surface of each specimen was moistened for 5 min or 24 h with 10 microl of the control or one of the four test solutions Olaflur, Oleaflur, sodium fluoride, or experimental fluoride containing hydrolyzed casein.
7(0,0,1,2) Details
17561043 Sudjalim TR, Woods MG, Manton DJ, Reynolds EC: Prevention of demineralization around orthodontic brackets in vitro. Am J Orthod Dentofacial Orthop. 2007 Jun;131(6):705.e1-9.

The purpose of this in-vitro study was to investigate the effect of sodium fluoride (Colgate Neutrafluor 9000 ppm) (NaF) and 10% casein phosphopeptide-amorphous calcium phosphate (GC Tooth Mousse) (TM) on enamel demineralization adjacent to orthodontic brackets.
6(0,0,1,1) Details
20178219 Bayrak S, Tunc ES, Sonmez IS, Egilmez T, Ozmen B: Effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) application on enamel microhardness after bleaching. Am J Dent. 2009 Dec;22(6):393-6.

3(0,0,0,3) Details
18362316 Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, Reynolds C: Fluoride and casein phosphopeptide-amorphous calcium phosphate. . J Dent Res. 2008 Apr;87(4):344-8.

2(0,0,0,2) Details
16508274 Lennon AM, Pfeffer M, Buchalla W, Becker K, Lennon S, Attin T: Effect of a casein/calcium phosphate-containing tooth cream and fluoride on enamel erosion in vitro. Caries Res. 2006;40(2):154-7.

2(0,0,0,2) Details
10627997 Meyer-Fernandes JR, da Silva-Neto MA, Soares Mdos S, Fernandes E, Vercesi AE, de Oliveira MM: Ecto-phosphatase activities on the cell surface of the amastigote forms of Trypanosoma cruzi. Z Naturforsch C. 1999 Nov;54(11):977-84.

Live Trypanosoma cruzi amastigotes hydrolyzed p-nitrophenylphosphate (PNPP), phospho-amino-acids and 32P-casein under physiologically appropriate conditions.
The Mg-dependent PNPP hydrolysis was strongly inhibited by sodium fluoride (NaF), vanadate and Zn2+ but not by tartrate and levamizole.
2(0,0,0,2) Details