Protein Information

Name amelogenin
Synonyms AIH 1; AIH1; ALGN; AMELX; AMG; AMGL; AMGX; Amelogenesis imperfecta 1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
8740536 Matsuo S, Inai T, Kurisu K, Kiyomiya K, Kurebe M: Influence of fluoride on secretory pathway of the secretory ameloblast in rat incisor tooth germs exposed to sodium fluoride. J Dent Res. 2008 Jan;87(1):39-44.

To define the influence of fluoride on the secretory pathway in enamel fluorosis, mottled enamel was induced in the incisor tooth germs of rats by subcutaneous injections of sodium fluoride for 4 days, and then morphological and cytochemical changes of the secretory ameloblast were examined in the tooth germs with HRP-labeled lectin (Con A, GS-I, SBA and PNA) and En3 antibody labeling amelogenins.
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18096891 Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P: Effects of fluoride on the interactions between amelogenin and apatite crystals. 380.

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16674670 Zhang Y, Yan Q, Li W, DenBesten PK: Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro. Eur J Oral Sci. 2006 May;114 Suppl 1:105-10; discussion 127-9


Fluorosed enamel has increased porosity, which has been related to a delay in the removal of amelogenin proteins as the enamel matures.
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19089147 Hassunuma RM, Zen Filho EV, Ceolin DS, Cestari TM, Taga R, de Assis GF: Ultrastructural and immunohistochemical study of the influence of fluoride excess on the development of rat incisor tooth buds. Arch Toxicol. 1996;70(7):420-9.

In the present study, female rats received 0 (control), 7 or 100 ppm of sodium fluoride in drinking water, one week before breeding and throughout gestation and nursing periods.
The hemimandibles of the offspring were collected at 0, 7 and 14 days of postnatal life (n = 5) and processed for morphological analyses by light and electron microscopy, immunohistochemical analysis for amelogenin and morphometric study of enamel matrix and ameloblasts of incisors.
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