Protein Information

Name glyceraldehyde 3 phosphate dehydrogenase
Synonyms CDABP0047; G3PD; GAPD; GAPD protein; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; GAPD proteins; Glyceraldehyde 3 phosphate dehydrogenases

Compound Information

Name acrylonitrile
CAS 2-propenenitrile

Reference List

PubMed Abstract RScore(About this table)
12204582 Campian EC, Cai J, Benz FW: Acrylonitrile irreversibly inactivates glyceraldehyde-3-phosphate dehydrogenase by alkylating the catalytically active cysteine 149. Chem Biol Interact. 2002 Aug 15;140(3):279-91.
85(1,1,1,5) Details
18834918 Campian EC, Benz FW: The acute lethality of acrylonitrile is not due to brain metabolic arrest. Toxicology. 2008 Nov 20;253(1-3):104-9. Epub 2008 Sep 9.

Previous work in our laboratory has shown that AN can irreversibly inactivate the catalytically active cysteine-149 in glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
2(0,0,0,2) Details