| Name | bradykinin |
|---|---|
| Synonyms | Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10027949 | Renaux JL, Thomas M, Crost T, Loughraieb N, Vantard G: Activation of the kallikrein-kinin system in hemodialysis: role of membrane electronegativity, blood dilution, and pH. Kidney Int. 1999 Mar;55(3):1097-103. METHODS: Plasma kallikrein activity using chromogenic substrate (S2302) and plasma bradykinin concentration (enzyme immuno assay) were measured during the perfusion of human plasma (2.5 ml/min) through minidialyzers mounted with six different membranes [polyacrylonitrile (PAN) from Asahi (PANDX) and from Hospal (AN69), polymethylmethacrylate (PMMA) from Toray, cellulose triacetate (CT) from Baxter, cuprophane (CUP) from Akzo and polysulfone (PS) from Fresenius]. |
3(0,0,0,3) | Details |
| 10458510 | Blais C Jr, Marc-Aurele J, Simmons WH, Loute G, Thibault P, Skidgel RA, Adam A: Des-Arg9-bradykinin metabolism in patients who presented hypersensitivity reactions during hemodialysis: role of serum ACE and aminopeptidase P. Peptides. 1999;20(4):421-30. |
2(0,0,0,2) | Details |
| 18078988 | Desormeaux A, Moreau ME, Lepage Y, Chanard J, Adam A: The effect of electronegativity and angiotensin-converting enzyme inhibition on the kinin-forming capacity of polyacrylonitrile dialysis membranes. Biomaterials. 2008 Mar;29(9):1139-46. The combination of negatively-charged membranes and angiotensin I-converting enzyme inhibitors (ACEi) evokes hypersensitivity reactions (HSR) during hemodialysis and bradykinin (BK)-related peptides have been hypothesized as being responsible for these complications. |
2(0,0,0,2) | Details |
| 10879671 | Kammerl MC, Schaefer RM, Schweda F, Schreiber M, Riegger GA, Kramer BK: Extracorporal therapy with AN69 membranes in combination with ACE inhibition causing severe anaphylactoid reactions: still a current problem?. Clin Nephrol. 2000 Jun;53(6):486-8. Underlying reasons are mainly the induction of bradykinin release due to the negatively charged membrane and the reduced degradation of bradykinin due to ACE inhibition. |
1(0,0,0,1) | Details |
| 1762316 | Parnes EL, Shapiro WB: Anaphylactoid reactions in hemodialysis patients treated with the AN69 dialyzer. Kidney Int. 1991 Dec;40(6):1148-52. Possible causes for AR are discussed and include: (1.) blood-AN69 membrane interaction leading to the production of bradykinin and other vasodilators, the breakdown of which may be delayed by the presence of ACE inhibitors; (2.) hypersensitivity to ethylene oxide; (3.) passage of bacterial products from dialysate to blood; (4.) changes in membrane manufacturing specifications. |
1(0,0,0,1) | Details |
| 2266684 | Tielemans C, Madhoun P, Lenaers M, Schandene L, Goldman M, Vanherweghem JL: Anaphylactoid reactions during hemodialysis on AN69 membranes in patients receiving ACE inhibitors. Kidney Int. 1990 Nov;38(5):982-4. These anaphylactoid reactions could be due to bradykinin accumulation, as a result of both increased synthesis--by interaction of blood with the AN69 polymer--and catabolism blockade by ACE inhibitors. |
1(0,0,0,1) | Details |
| 7623993 | Krieter DH, Fink E, Bonner G, You HM, Eisenhauer T: Anaphylactoid reactions during haemodialysis in sheep are associated with bradykinin release. Nephrol Dial Transplant. 1995;10(4):509-13. |
8(0,0,0,8) | Details |
| 8141183 | Schaefer RM, Fink E, Schaefer L, Barkhausen R, Kulzer P, Heidland A: Role of bradykinin in anaphylactoid reactions during hemodialysis with AN69 dialyzers. Am J Nephrol. 1993;13(6):473-7. |
5(0,0,0,5) | Details |
| 8559490 | Van der Niepen P, Sennesael JJ, Verbeelen DL: Kinin kinetics during different dialysis protocols with AN69 dialyser in ACEI-treated patients. Nephrol Dial Transplant. 1995;10(9):1689-95. During dialysis, serum pH, albumin, and bradykinin were measured at the start and after 5 min at arterial, venous, and postinfusion side of the extracorporeal circuit. |
4(0,0,0,4) | Details |