Protein Information

Name beta 2 microglobulin
Synonyms B2M; Beta 2 microglobulin; Beta 2 microglobulin precursor; CDABP0092; HDCMA22P; Beta 2 microglobulins; Beta 2 microglobulin precursors

Compound Information

Name acrylonitrile
CAS 2-propenenitrile

Reference List

PubMed Abstract RScore(About this table)
2197235 Kandus A, Ponikvar R, Drinovec J, Pavlin K, Ivanovich P: Beta 2-microglobulin elimination characteristics during hemofiltration with acrylonitrile and polysulfone membrane hemofilters. Int J Artif Organs. 1990 Apr;13(4):200-4.
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3147420 Floege J, Wilks M, Shaldon S, Koch KM, Smeby LC: Beta 2-microglobulin kinetics during haemofiltration. Nephrol Dial Transplant. 1988;3(6):784-9.

To study the kinetics of beta 2-microglobulin during haemofiltration, seven patients with end-stage renal failure were treated with the AN 69 (acrylonitrile), Duo-Flux (cellulose acetate) and F 60 (polysulphone) haemofilter.
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3293621 Jorstad S, Smeby LC, Balstad T, Wideroe TE: Removal, generation and adsorption of beta-2-microglobulin during hemofiltration with five different membranes. Blood Purif. 1988;6(2):96-105.

Removal of beta 2-microglobulin (B2MG) from uremic plasma during hemofiltration in 5 patients using polysulfone (F60), acrylonitrile (AN69), polyamid (FH77), polyacrylonitrile (PAN200) and cellulose-acetate (Duo-Flux) membranes was investigated.
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8186494 Lee CJ, Hsiong CH, Chang YL, Cheng CH, Lian JD: Statistical and parametric analysis of beta-2-microglobulin removal from uremic patients in high flux hemodialysis. ASAIO J. 1994 Jan-Mar;40(1):62-6.

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8559492 Ferreira A, Urena P, Ang KS, Simon P, Morieux C, Souberbielle JC, de Vernejoul MC, Drueke TB: Relationship between serum beta 2-microglobulin, bone histology, and dialysis membranes in uraemic patients. Nephrol Dial Transplant. 1995;10(9):1701-7.

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8381935 Ward RA, Schaefer RM, Falkenhagen D, Joshua MS, Heidland A, Klinkmann H, Gurland HJ: Biocompatibility of a new high-permeability modified cellulose membrane for haemodialysis. Nephrol Dial Transplant. 1993;8(1):47-53.

The biocompatibility and solute permeability characteristics of a high-permeability modified cellulose membrane (Hemophan-HP) (He-HP) were compared with those of two synthetic membranes (poly (ethylene-co-vinyl alcohol) (EVAL) and poly (acrylonitrile-co-sodium methallyl sulphonate) (AN69)) and Cuprophan in a multicentre, four-way cross-over clinical trial.
In contrast, Cuprophan was essentially impermeable to beta 2-microglobulin, whereas He-HP, EVAL, and AN69 allowed the removal of 60-90 mg of beta 2-microglobulin per treatment.
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2510064 Floege J, Granolleras C, Deschodt G, Heck M, Baudin G, Branger B, Tournier O, Reinhard B, Eisenbach GM, Smeby LC, et al.: High-flux synthetic versus cellulosic membranes for beta 2-microglobulin removal during hemodialysis, hemodiafiltration and hemofiltration. Nephrol Dial Transplant. 1989;4(7):653-7.

To evaluate comparative beta 2-M removal we studied six stable end-stage renal failure patients during high-flux 3-h haemodialysis, haemodia-filtration, and haemofiltration, using acrylonitrile, cellulose triacetate, polyamide and polysulphone capillary devices.
2(0,0,0,2) Details
9151148 Ronco C, Heifetz A, Fox K, Curtin C, Brendolan A, Gastaldon F, Crepaldi C, Fortunato A, Pietribasi G, Caberlotto A, Brunello A, Milan Manani S, Zanella M, La Greca G: Beta 2-microglobulin removal by synthetic dialysis membranes. Int J Artif Organs. 1997 Mar;20(3):136-43.

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7923985 Floege J, Koch KM: Beta 2-microglobulin associated amyloidosis and therapy with high flux hemodialysis membranes. Clin Nephrol. 1994 Jul;42 Suppl 1:S52-6.

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2702129 Goldman M, Nortier J, Dhaene M, Amraoui Z, Vanherweghem JL: Fate of beta-2-microglobulin during dialysis on polysulfone and AN69 membranes. Contrib Nephrol. 1989;74:127-31.

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7530999 Mahiout A, Courtney JM: Effect of dialyser membranes on extracellular and intracellular granulocyte and monocyte activation in ex vivo pyrogen-free conditions. Biomaterials. 1994 Oct;15(12):969-80.

Membrane materials were the unchanged regenerated cellulose, the synthetic polysulphone (PS), a positively charged diethylaminoethyl cellulose (DEAE-C), the negatively charged carboxymethyl cellulose (CMC) and acrylonitrile copolymer (AN).
The intracellular activation of peripheral blood mononuclear cells was done by mRNA transcription of IL-1 beta, TNF-alpha, IL-6, IL-8 and beta 2-microglobulin (beta 2-MG).
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3126461 Goldman M, Dhaene M, Vanherweghem JL: Removal of beta 2-microglobulin by adsorption on dialysis membranes. Nephrol Dial Transplant. 1987;2(6):576-7.

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12218339 Senatore M, Nicoletti A, Rizzuto G: Is the bioreactivity of vitamin-E-modified dialyzer an expression of increased plasmatic vitamin E concentration?. Nephron. 2002 Oct;92(2):487-9.

The present study was designed to test the biocompatibility of a new vitamin E-modified multilayer membrane compared with highly biocompatible polysulphone dialyzer and acrylonitrile dialyzer.
Vitamin E-coated dialyzer causes significant decreases in beta (2)-microglobulin, ferritin and immunoglobulin G, a normalization of complement C3 and an increase of plasmatic vitamin E compared to other filters.
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9895432 Campistol JM, Torregrosa JV, Ponz E, Fenollosa B: Beta-2-microglobulin removal by hemodialysis with polymethylmethacrylate membranes. Contrib Nephrol. 1999;125:76-85.

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