| Name | Cytochrome c oxidase (protein family or complex) |
|---|---|
| Synonyms | COX; cytochrome c oxidase; cytochrome c oxidases |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10977952 | Zabrodskii PF, Kirichuk VF, Germanchuk VG, Belikov VG: Mechanisms of immunotoxic effects of acrylonitrile. . Bull Exp Biol Med. 2000 May;129(5):463-5. The main mechanism of immunotoxic effect of acrylonitrile is mediated through inhibition of T lymphocyte esterases and a (3) component of cytochrome c oxidase of immunocyte mitochondrial respiration enzymes, which is important for prevention and treatment of immune disturbances caused by this toxin. |
81(1,1,1,1) | Details |
| 6287676 | Ahmed AE, Farooqui MY: Comparative toxicities of aliphatic nitriles. Toxicol Lett. 1982 Jul;12(2-3):157-63. We have investigated the signs of toxicity and effect of equitoxic LD50 doses of saturated and unsaturated aliphatic mono- and dinitriles on tissue and blood levels, tissue levels and cytochrome c oxidase activities. Hepatic and blood levels 1 h after treatment were highest following malononitrile (MCN) and decreased in the order of propionitrile (PCN) greater than KCN greater than butyronitrile greater than acrylonitrile (VCN) greater than allylcyanide greater than greater than fumaronitrile greater than acetonitrile. |
2(0,0,0,2) | Details |
| 19913070 | Guangwei X, Rongzhu L, Wenrong X, Suhua W, Xiaowu Z, Shizhong W, Ye Z, Aschner M, Kulkarni SK, Bishnoi M: pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology. 2010 Jan 12;267(1-3):140-6. Epub 2009 Nov 11. Furthermore, effectively prevented AN-induced decrease in cytochrome c oxidase activity in both liver and brain. |
1(0,0,0,1) | Details |
| 20127315 | Suhua W, Rongzhu L, Wenrong X, Guangwei X, Xiaowu Z, Shizhong W, Ye Z, Fangan H, Aschner M: Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence. Arch Toxicol. 2010 Feb 3. The cytochrome c oxidase (CcOx) activities in the brains and livers of the rats treated with AN or AN + were significantly lower than those in the normal control rats and the rats treated with DCE, whereas the CcOx activities in the brains and livers of rats with decreased CYP2E1 activity were significantly higher than those in AN-treated rats. |
1(0,0,0,1) | Details |