| Name | GSTT1 |
|---|---|
| Synonyms | GST class theta; GST class theta 1; GSTT 1; GSTT1; GSTT1 protein; Glutathione S transferase theta 1; Glutathione transferase T1 1; glutathione S transferase T1… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10919741 | Fennell TR, MacNeela JP, Morris RW, Watson M, Thompson CL, Bell DA: Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):705-12. |
12(0,0,1,7) | Details |
| 10463383 | Thier R, Lewalter J, Kempkes M, Selinski S, Bruning T, Bolt HM: Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1. Arch Toxicol. 1999 Jun-Jul;73(4-5):197-202. |
8(0,0,1,3) | Details |
| 10698723 | Sram RJ, Binkova B: Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999. Environ Health Perspect. 2000 Mar;108 Suppl 1:57-70. Biomarkers evaluated were selected according to basic scheme: biomarkers of exposure--metabolites in urine, DNA adducts, protein adducts, and Comet assay parameters; biomarkers of effect--chromosomal aberrations, sister chromatid exchanges, micronuclei, mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, and the activation of oncogenes coding for p53 or p21 proteins as measured on protein levels; biomarkers of susceptibility--genetic polymorphisms of genes CYP1A1, GSTM1, GSTT1, NAT2. Protein adducts are useful as a biomarker for exposure to tobacco smoke (4-aminobiphenyl) or to smaller molecules such as acrylonitrile or 1,3-butadiene. |
1(0,0,0,1) | Details |
| 11535247 | Thier R, Balkenhol H, Lewalter J, Selinski S, Dommermuth A, Bolt HM: Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Mutat Res. 2001 Oct 1;482(1-2):41-6. The study also confirmed the impact of GSTT1 polymorphism on background N-(hydroxyethyl)- adduct levels in haemoglobin which are caused by endogenous ethylene oxide. |
1(0,0,0,1) | Details |
| 12034325 | Rossner P jr, Binkova B, Chvatalova I, Sram RJ: Acrylonitrile exposure: the effect on p53 and p21 (WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts. Mutat Res. 2002 May 27;517(1-2):239-50. |
0(0,0,0,0) | Details |