Protein Information

Name glutathione S transferase alpha 1
Synonyms GST class alpha 1; Gst2; GST class alpha; GST class alpha member 1; GST epsilon; GSTA 1; GSTA1; GSTA1 protein…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
18784548 Jonsson LS, Littorin M, Axmon A, Jonsson BA, Broberg K: Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden. J Occup Environ Med. 2008 Sep;50(9):1006-12.

Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry.
The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114.
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17333241 Jonsson LS, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson BA: Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007 Jul;80(7):589-98. Epub 2007 Feb 28.

One of the toxic compounds in the industry is carbon disulfide (CS (2)), which is biotransformed to 2-thiothiazolidine-4-carboxylic acid (TTCA).
Genotyping of the single nucleotide polymorphisms GCLC-129, GCLM-588, GSTA1-52, GSTP1-105 and GSTP1-114 and deletions of GSTM1 and GSTT1 were performed with real-time PCR or ordinary PCR and subsequent agarose electrophoresis.
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