Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
847430 Juntunen J, Linnoila I, Haltia M: Histochemical and electron microscopic observations on the myoneural junctions of rats with carbon disulfide induced polyneuropathy. Scand J Work Environ Health. 1977 Mar;3(1):36-42.

It thus seems that systemic carbon disulfide poisoning primarily alters the presynaptic structures of the myoneural junctions, while the postsynaptic side remains relatively intact, especially since the histochemical distribution of AChE in myoneural junctions was normal.
7(0,0,1,2) Details
923688 Dietzmann K, Laass W: Histological and histochemical studies on the rat brain under conditions of carbon disulfide intoxication. Exp Pathol. 1977;13(6):320-7.

The histochemical assays for enzyme activities of monoamine oxidase, ATPase, glucose 6-phosphatase, acetylcholine esterase and succinic dehydrogenase in the entire central nervous system revealed values identical to those obtained for control animals.
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2897731 Costa LG: Interactions of neurotoxicants with neurotransmitter systems. Toxicology. 1988 May;49(2-3):359-66.

Chemicals which have been shown to alter neurotransmission include solvents (e.g. carbon disulfide), metals and organometals (e.g. lead, mercury, trimethyltin) and pesticides (e.g. organophosphates, pyrethroids, organochlorines, formamidines).
Organophosphorus insecticides owe their acute toxicity to inhibition of acetylcholinesterase and accumulation of acetylcholine at cholinergic receptors.
1(0,0,0,1) Details