Protein Information

Name GSTM1
Synonyms GST class mu 1; Glutathione S alkyltransferase; MU; GST1; GSTM 1; GSTM1; GSTM1 protein; GSTM1 1…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
18784548 Jonsson LS, Littorin M, Axmon A, Jonsson BA, Broberg K: Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden. J Occup Environ Med. 2008 Sep;50(9):1006-12.

Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry.
GSTM1 had an influence on lung function among unexposed workers.
1(0,0,0,1) Details
17333241 Jonsson LS, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson BA: Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007 Jul;80(7):589-98. Epub 2007 Feb 28.

One of the toxic compounds in the industry is carbon disulfide (CS (2)), which is biotransformed to 2-thiothiazolidine-4-carboxylic acid (TTCA).
Genotyping of the single nucleotide polymorphisms GCLC-129, GCLM-588, GSTA1-52, GSTP1-105 and GSTP1-114 and deletions of GSTM1 and GSTT1 were performed with real-time PCR or ordinary PCR and subsequent agarose electrophoresis.
2(0,0,0,2) Details