Protein Information

Name isocitrate dehydrogenase
Synonyms ICD M; IDH; IDP; NADP(+) specific ICDH; Oxalosuccinate decarboxylase; IDH 2; IDH2; IDHM…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
3427047 Bailey JM, Colman RF: 2-[(4-Bromo-2,3-dioxobutyl) thio]- and 2-[(3-bromo-2-oxopropyl) thio] adenosine 2'5'-bisphosphate: new nucleotide analogues that act as affinity labels of nicotinamide adenine dinucleotide phosphate specific isocitrate dehydrogenase. Biochemistry. 1987 Oct 20;26(21):6858-69.

Treatment with NaOH followed by reaction with carbon disulfide yielded 2-thioadenosine 2',5'-bisphosphate (TA-2',5'-DP).
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3771526 Huang YC, Bailey JM, Colman RF: Inactivation of NAD-dependent isocitrate dehydrogenase by affinity labeling of the allosteric ADP site by 2-(4-bromo-2,3-dioxobutylthio) adenosine 5'-diphosphate. J Biol Chem. 1986 Oct 25;261(30):14100-7.

Reaction of ADP with m-chloroperoxybenzoic acid gave ADP 1-oxide, which was treated with NaOH, followed by reaction with carbon disulfide to yield 2-thioadenosine 5'-diphosphate.
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