Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
3109439 Furukawa N, Nakamura H, Sato M, Suzuki Y: Induction of the hepatic microsomal cytochrome P-450 system by trialkyl phosphorothioates in rats. Biochem Pharmacol. 1987 Apr 15;36(8):1291-6.

Single i.p. doses of O,O,O-triethyl phosphorothioate [OOO-Et (S)], one of the suicide substrates for cytochrome P-450, caused a rapid increase of NADPH-cytochrome c reductase activity in rat liver microsomes.
Triethyl phosphate, the oxygen analog of OOO-Et (S), also caused an increase of the reductase activity, but carbon disulfide had no influence on this activity.
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7406873 Obrebska MJ, Kentish P, Parke DV: The effects of carbon disulphide on rat liver microsomal mixed-function oxidases, in vivo and in vitro. Biochem J. 1980 Apr 15;188(1):107-12.


Losses of NADPH-cytochrome c reductase (20%) and cytochrome b (5) were considerably less.
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3778518 Masuda Y, Yasoshima M, Nakayama N: Early, selective and reversible suppression of cytochrome P-450-dependent monooxygenase of liver microsomes following the administration of low doses of carbon disulfide in mice. Biochem Pharmacol. 1986 Nov 15;35(22):3941-7.

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