Protein Information

Name survivin
Synonyms API 4; API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC 5; BIRC5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat containing protein 5 isoform 1…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
20133811 Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster BA, Johnson CS, Rustum YM, Porter CW: Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol. 2010 Apr;176(4):1629-38. Epub 2010 Feb 4.

Significantly, it was reported that survivin expression turns on during mouse liver injury and regeneration; a transient and dose-dependent luciferase expression in the mouse liver was observed after administration of carbon tetrachloride into SPlucTg mice.
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17938867 Marsillach J, Ferre N, Camps J, Rull A, Beltran R, Joven J: Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Mol Cell Biochem. 2008 Jan;308(1-2):101-9. Epub 2007 Oct 16.


Recovery after CCl (4) cessation was associated with changes in procollagen type I alpha 2, matrix metalloproteinase 7, tissue inhibitors of metalloproteinases 1 and 2, inhibitor of apoptosis 4, and survivin gene expressions.
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17484886 De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF: Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May;132(5):1937-46. Epub 2007 Feb 21.


RESULTS: Two thousand seventy-three probe sets were differentially expressed in at least 1 of 3 models of HSC activation, including novel genes that encode proinflammatory and antiapoptotic mediators; transcription factors; cell surface receptors; and cytoskeleton components such as CXCL14, survivin, septin 4, osteopontin, PRX1, LMCD1, GPR91, leiomodin, and anillin.
1(0,0,0,1) Details