Protein Information

Name endothelial nitric oxide synthase
Synonyms Constitutive NOS; NOS 3; NOS3; EC NOS; ECNOS; ENOS; Endothelial NOS; Endothelial nitric oxidase synthase…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
19527736 Cho YK, Yun JW, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Jin W, Kwon YH, Shin MK, Yoo TM, Kang JH, Park CS: Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers. Life Sci. 2009 Aug 12;85(7-8):281-90. Epub 2009 Jun 13.
6(0,0,1,1) Details
19628654 Theodorakis NG, Wang YN, Wu JM, Maluccio MA, Sitzmann JV, Skill NJ: Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride induced liver fibrosis model. Am J Physiol Gastrointest Liver Physiol. 2009 Jul 23.
6(0,0,1,1) Details
18070013 Zhang ZQ, Qiu JF, Luo M, Sun YW, Zhao G, Chen W, Liu H, Wu ZY: Liposome-mediated gene transfer of endothelial nitric oxide synthase to cirrhotic rat liver decreases intrahepatic vascular resistance. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e487-93. Epub 2007 Dec 7.

METHODS: Hepatic cirrhosis was induced in male Sprague-Dawley rats by intraperitoneal injection of carbon tetrachloride (CCl (4)), whereas the control normal rats were given the same dose of peanut oil.
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18429990 Leung TM, Tipoe GL, Liong EC, Lau TY, Fung ML, Nanji AA: Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis. Int J Exp Pathol. 2008 Aug;89(4):241-50. Epub 2008 Apr 21.

Chronic liver injury was induced by administration of carbon tetrachloride (CCl (4)) to mice for 8 weeks. 5-Methylisothiourea hemisulphate (SMT), an iNOS inhibitor, or L-arginine, a NOS substrate were injected subcutaneously.
2(0,0,0,2) Details
18412020 Knorr A, Hirth-Dietrich C, Alonso-Alija C, Harter M, Hahn M, Keim Y, Wunder F, Stasch JP: Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80.

However, cGMP production is downregulated in the cirrhotic liver due to the reduced activity of the endothelial nitric oxide synthase.
METHODS: The compound was studied in the pig serum model and the carbon tetrachloride model.
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16698588 Yuan GJ, Gong ZJ, Sun XM, Zheng SH, Li X: Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int. 2006 May;5(2):262-7.

BACKGROUND: Tea polyphenols have been shown to protect against carbon tetrachloride (CCl4)-induced liver injury, liver fibrosis, hepatic ischemia-reperfusion injury.
Inducible nitric oxide synthase (iNOS) protein and TNF-alpha, iNOS and endothelial nitric oxide synthase (eNOS) mRNA expressions in the liver were detected by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
1(0,0,0,1) Details
19401196 Zhang ZQ, Shi B, Wu GQ, Qin KR, Jiang ZL, Zhu L: Combined use of propranolol and nifedipine offers better effects on portal vein nonuniform remodeling in carbon tetrachloride (CCl (4))-induced portal hypertensive rats. Eur J Pharmacol. 2009 Jun 24;613(1-3):108-13. Epub 2009 May 3.

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18317400 Liu H, Subramony C, Nowicki M: Posttranslational activation of endothelial nitric oxide synthase attenuates carbon tetrachloride-induced hepatotoxicity in newborn rats. Pediatr Res. 2008 Jun;63(6):613-9.
81(1,1,1,1) Details