| Name | prothrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15479692 | Duplantier JG, Dubuisson L, Senant N, Freyburger G, Laurendeau I, Herbert JM, Desmouliere A, Rosenbaum J: A role for thrombin in liver fibrosis. . Gut. 2004 Nov;53(11):1682-7. |
5(0,0,0,5) | Details |
| 16688827 | Lin WC, Kuo SC, Lin WL, Fang HL, Wang BC: Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol. 2006 Apr 21;12(15):2369-74. Spleen weight, blood synthetic markers (albumin and prothrombin time) and hepatic malondialdehyde (MDA) and (HP) concentrations were determined. |
3(0,0,0,3) | Details |
| 17962354 | Rullier A, Gillibert-Duplantier J, Costet P, Cubel G, Haurie V, Petibois C, Taras D, Dugot-Senant N, Deleris G, Bioulac-Sage P, Rosenbaum J: Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G226-35. Epub 2007 Oct 25. Thrombin inhibition protects against liver fibrosis. Acute carbon tetrachloride (CCl (4)) toxicity was similar in wild-type (WT), PAR-1 (-/-), and PAR-1 (+/-) mice as judged by aminotransferase levels, area of liver necrosis, and liver peroxidation measured by Fourier-transformed infrared spectroscopy. |
2(0,0,0,2) | Details |
| 18675126 | Nardo B, Tsivian M, Neri F, Piras G, Pariali M, Bertelli R, Cavallari G: Extracorporeal portal vein oxygenation improves outcome of acute liver failure in swine. Transplant Proc. 2008 Jul-Aug;40(6):2046-8. Control group animals deteriorated biochemically, dropping their prothrombin times and increasing the liver enzymes. MATERIALS AND METHODS: The 2 ALF swine models were carbon tetrachloride toxic ALF and subtotal hepatectomy using 8 animals per group. |
1(0,0,0,1) | Details |
| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. In addition, all levels of serum serum albumin, triglyceride (TG), total (TC), platelet count (PLT), and prothrombin time (PT) except TG were shown effectively restored to normal values by CC-700C and Silymarin. |
1(0,0,0,1) | Details |
| 17313811 | Hu AB, He XS, Zheng QC, Cai JY: [Curative effects of transplantation of hepatocytes differentiated from embryonic stem cells on treatment of fulminant hepatic failure: experiment with mice]. Zhonghua Yi Xue Za Zhi. 2006 Dec 12;86(46):3280-4. Twenty-four hours later venous blood samples were collected to examine the levels of total (TB), alanine aminotransferase (ALT), ALB, blood sugar (BS), and prothrombin time (PT). Twenty-four hours later carbon tetrachloride was injected intra-peritoneally to induce FHF. |
1(0,0,0,1) | Details |
| 19058329 | Regimbeau JM, Fuks D, Kohneh-Shahri N, Terris B, Soubrane O: Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats. World J Gastroenterol. 2008 Dec 7;14(45):6943-7. Prothrombin time (PT) and total (TB) were also evaluated. |
1(0,0,0,1) | Details |
| 18485088 | Anstee QM, Goldin RD, Wright M, Martinelli A, Cox R, Thursz MR: Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies. J Thromb Haemost. 2008 Aug;6(8):1336-43. Epub 2008 May 14. It is likely that thrombin signaling through the proteinase-activated receptor 1 (PAR (1)) receptor expressed on hepatic stellate cells is responsible for this relationship. Prothrombotic FV Leiden mutant mice, C57BL/6 control animals and anticoagulated mice were studied after chronic exposure to carbon tetrachloride. |
1(0,0,0,1) | Details |
| 15860571 | Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R: A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. Epub 2005 Apr 28. Exposure of HSCs to FXR ligands increases small heterodimer partner (SHP) mRNA by 3-fold and reduces basal and thrombin-stimulated expression of alpha1 (I) collagen, alpha-smooth muscle actin (alpha-SMA), TIMP-1, and TIMP-2 by approximately 60 to 70%, whereas it increased matrix metalloprotease (MMP)-2 activity by 2-fold. |
1(0,0,0,1) | Details |
| 18023088 | Li LJ, Yang YG, Zhang ZL, Nie SF, Li Z, Li F, Hua HY, Hu YJ, Zhang HS, Guo YB: Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs. World J Gastroenterol. 2007 Dec 7;13(45):5989-94. AIM: To investigate the protective effect of medical ozone (O (3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl (4))-induced hepatic injury in dogs. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/alanine aminotransferase (AST/ALT), serum total (TBIL), prothrombin time (PT), blood (AMMO), and blood urea (BUN) were measured after CCl (4) injection. |
1(0,0,0,1) | Details |
| 15483417 | Ritter C, Reinke A, Andrades M, Martins MR, Rocha J, Menna-Barreto S, Quevedo J, Moreira JC, Dal-Pizzol F: Protective effect of and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. Crit Care Med. 2004 Oct;32(10):2079-83. In addition, the serum levels of alanine aminotransferase, total and prothrombin time in the plus deferoxamine group were significantly lower than those in the or deferoxamine and saline groups. |
1(0,0,0,1) | Details |
| 19718641 | Liu F, Liu ZD, Wu N, Cong X, Fei R, Chen HS, Wei L: Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats. Liver Transpl. 2009 Sep;15(9):1092-100. CCl (4) treatment increased the international prothrombin ratio (P < 0.05) and reduced albumin levels, whereas EPCs restored these parameters to normal levels. |
1(0,0,0,1) | Details |